Abnormal maternal behavior, altered sociability, and impaired serotonin metabolism in Rai1-transgenic mice

Abnormal maternal behavior, altered sociability, and impaired serotonin metabolism in... Dup(17)(p11.2) syndrome, consisting of a spectrum of more than 20 clinical features, is associated with increased dosage of the retinoic acid induced 1 (RAI1) gene. We previously reported on the generation and evaluation of Rai1-overexpressing mice. Several phenotypes, including increased anxiety and hyperactivity, growth retardation, and altered motor and sensory coordination, were observed, recapitulating phenotypes observed in patients with 17p11.2 duplication. In addition, these mice have reduced reproductive fitness. In this study we expand investigations to identify possible neural correlates for increased Rai1 dosage. We analyzed Rai1-transgenic breeding data and evaluated maternal and social behaviors as potential causes for reduced litter size in Rai1 transgenics compared to wild-type controls. Abnormal maternal behavior, including delayed pup retrieval in the Rai1-transgenic dams compared to wild-type dams, was identified. Mendelian transmission of parental genotypes was also distorted in the pups from transgenic breeding. Furthermore, altered social behavior was observed in the male transgenic mice. Analysis of neurotransmitter levels from whole-brain lysates showed significantly impaired serotonin metabolism indicating a neuronal basis for behavioral modifications in these mice. Our study suggests an important role for Rai1 in the serotonin pathway in a dosage-dependent manner. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Abnormal maternal behavior, altered sociability, and impaired serotonin metabolism in Rai1-transgenic mice

Loading next page...
 
/lp/springer_journal/abnormal-maternal-behavior-altered-sociability-and-impaired-serotonin-NZ52Agxfms
Publisher
Springer-Verlag
Copyright
Copyright © 2009 by Springer Science+Business Media, LLC
Subject
Life Sciences; Zoology ; Anatomy ; Cell Biology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s00335-009-9180-y
Publisher site
See Article on Publisher Site

Abstract

Dup(17)(p11.2) syndrome, consisting of a spectrum of more than 20 clinical features, is associated with increased dosage of the retinoic acid induced 1 (RAI1) gene. We previously reported on the generation and evaluation of Rai1-overexpressing mice. Several phenotypes, including increased anxiety and hyperactivity, growth retardation, and altered motor and sensory coordination, were observed, recapitulating phenotypes observed in patients with 17p11.2 duplication. In addition, these mice have reduced reproductive fitness. In this study we expand investigations to identify possible neural correlates for increased Rai1 dosage. We analyzed Rai1-transgenic breeding data and evaluated maternal and social behaviors as potential causes for reduced litter size in Rai1 transgenics compared to wild-type controls. Abnormal maternal behavior, including delayed pup retrieval in the Rai1-transgenic dams compared to wild-type dams, was identified. Mendelian transmission of parental genotypes was also distorted in the pups from transgenic breeding. Furthermore, altered social behavior was observed in the male transgenic mice. Analysis of neurotransmitter levels from whole-brain lysates showed significantly impaired serotonin metabolism indicating a neuronal basis for behavioral modifications in these mice. Our study suggests an important role for Rai1 in the serotonin pathway in a dosage-dependent manner.

Journal

Mammalian GenomeSpringer Journals

Published: Mar 25, 2009

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off