Ability of two novel α-amino acid-based tridentate ligands to complex Fe3+ in solution

Ability of two novel α-amino acid-based tridentate ligands to complex Fe3+ in solution Two novel α-amino acid-based tridentate ligands, L1 and L2, were synthesized, and characterized by use of spectroscopic methods. Potentiometric and spectrophotometric methods were used to study the pH-dependent protonation behavior of the ligands and their complexation towards Fe(III) in aqueous medium of ionic strength, µ = 0.1 M KCl at 25 ± 1 °C. The stability constants of complex species of the types FeLH3, FeLH2, FeLH, FeL, and FeL2 (L = L1 or L2) were determined, and probable structures of the ferric complexes were proposed on the basis of molecular modeling. The complexing ability of the ligands was compared with that of deferiprone (a drug used for medical treatment of iron intoxication) and transferrin (the main Fe-binding protein in plasma). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Ability of two novel α-amino acid-based tridentate ligands to complex Fe3+ in solution

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Publisher
Springer Netherlands
Copyright
Copyright © 2014 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-014-1689-3
Publisher site
See Article on Publisher Site

Abstract

Two novel α-amino acid-based tridentate ligands, L1 and L2, were synthesized, and characterized by use of spectroscopic methods. Potentiometric and spectrophotometric methods were used to study the pH-dependent protonation behavior of the ligands and their complexation towards Fe(III) in aqueous medium of ionic strength, µ = 0.1 M KCl at 25 ± 1 °C. The stability constants of complex species of the types FeLH3, FeLH2, FeLH, FeL, and FeL2 (L = L1 or L2) were determined, and probable structures of the ferric complexes were proposed on the basis of molecular modeling. The complexing ability of the ligands was compared with that of deferiprone (a drug used for medical treatment of iron intoxication) and transferrin (the main Fe-binding protein in plasma).

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 4, 2014

References

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