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S. Emerson, Hanh Nguyen, U. Torian, D. Burke, R. Engle, R. Purcell (2010)
Release of Genotype 1 Hepatitis E Virus from Cultured Hepatoma and Polarized Intestinal Cells Depends on Open Reading Frame 3 Protein and Requires an Intact PXXP MotifJournal of Virology, 84
X. Meng, P. Halbur, M. Shapiro, S. Govindarajan, J. Bruna, I. Mushahwar, R. Purcell, S. Emerson (1998)
Genetic and Experimental Evidence for Cross-Species Infection by Swine Hepatitis E VirusJournal of Virology, 72
H. Okamoto, Masaharu Takahashi, T. Nishizawa (2003)
Features of hepatitis E virus infection in Japan.Internal medicine, 42 11
Shuchin Tei, N. Kitajima, Kazuaki Takahashi, S. Mishiro (2003)
Zoonotic transmission of hepatitis E virus from deer to human beingsThe Lancet, 362
Paul Kwo, G. Schlauder, Herschel Carpenter, Paul Murphy, Jon Rosenblatt, George Dawson, Eric Mast, K. Krawczyński, Vijayan Balan (1997)
Acute hepatitis E by a new isolate acquired in the United States.Mayo Clinic proceedings, 72 12
K. Takahashi, A. Machida, G. Funatsu, M. Nomura, S. Usuda, S. Aoyagi, K. Tachibana, H. Miyamoto, M. Imai, T. Nakamura, Y. Miyakawa, M. Mayumi (1983)
Immunochemical structure of hepatitis B e antigen in the serum.Journal of immunology, 130 6
Masaharu Takahashi, Y. Hoshino, Toshinori Tanaka, Hideyuki Takahashi, T. Nishizawa, H. Okamoto (2008)
Production of monoclonal antibodies against hepatitis E virus capsid protein and evaluation of their neutralizing activity in a cell culture systemArchives of Virology, 153
Hou-Yong Zhang, Dong-Sheng Chen, Yi-quan Wu, Qigai He, Huan-chun Chen, Zheng-Fei Liu (2011)
Both swine and human cells are capable to support the replication of swine hepatitis E virus type 4 in vitro.Virus research, 158 1-2
X. Meng (2011)
From barnyard to food table: the omnipresence of hepatitis E virus and risk for zoonotic infection and food safety.Virus research, 161 1
J. Amon, J. Drobeniuc, W. Bower, Jorge Magaña, M. Escobedo, I. Williams, B. Bell, G. Armstrong (2006)
Locally acquired hepatitis E virus infection, El Paso, TexasJournal of Medical Virology, 78
J. Mansuy, J. Péron, F. Abravanel, H. Poirson, M. Dubois, M. Miédougé, F. Vischi, L. Alric, J. Vinel, J. Izopet (2004)
Hepatitis E in the south west of France in individuals who have never visited an endemic areaJournal of Medical Virology, 74
Y. Yazaki, H. Mizuo, Masaharu Takahashi, T. Nishizawa, N. Sasaki, Y. Gotanda, H. Okamoto (2003)
Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food.The Journal of general virology, 84 Pt 9
Hozumi Tanaka, H. Yoshino, E. Kobayashi, Masaharu Takahashi, H. Okamoto (2004)
Molecular investigation of hepatitis E virus infection in domestic and miniature pigs used for medical experiments *Xenotransplantation, 11
T. Williams, C. Kasorndorkbua, P. Halbur, G. Haqshenas, D. Guenette, T. Toth, X. Meng (2001)
Evidence of Extrahepatic Sites of Replication of the Hepatitis E Virus in a Swine ModelJournal of Clinical Microbiology, 39
P. Colson, P. Borentain, B. Queyriaux, M. Kaba, V. Moal, P. Gallian, L. Heyries, D. Raoult, R. Gérolami (2010)
Pig liver sausage as a source of hepatitis E virus transmission to humans.The Journal of infectious diseases, 202 6
N. Pavio, X. Meng, C. Renou (2010)
Zoonotic hepatitis E: animal reservoirs and emerging risksVeterinary Research, 41
Y. Tamada, K. Yano, H. Yatsuhashi, O. Inoue, F. Mawatari, H. Ishibashi (2004)
Consumption of wild boar linked to cases of hepatitis E.Journal of hepatology, 40 5
Toshinori Tanaka, Masaharu Takahashi, Hideyuki Takahashi, K. Ichiyama, Y. Hoshino, S. Nagashima, H. Mizuo, H. Okamoto (2009)
Development and Characterization of a Genotype 4 Hepatitis E Virus Cell Culture System Using a HE-JF5/15F Strain Recovered from a Fulminant Hepatitis PatientJournal of Clinical Microbiology, 47
Hiroyuki Matsuda, K. Okada, Kazuaki Takahashi, S. Mishiro (2003)
Severe hepatitis E virus infection after ingestion of uncooked liver from a wild boar.The Journal of infectious diseases, 188 6
J. Wenzel, J. Preiss, M. Schemmerer, B. Huber, A. Plentz, W. Jilg (2011)
Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 52 1
N. Kamar, J. Selves, J. Mansuy, Leila Ouezzani, J. Péron, J. Guitard, O. Cointault, L. Esposito, F. Abravanel, M. Danjoux, D. Durand, J. Vinel, J. Izopet, L. Rostaing (2008)
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.The New England journal of medicine, 358 8
J. Graff, U. Torian, Hanh Nguyen, S. Emerson (2006)
A Bicistronic Subgenomic mRNA Encodes both the ORF2 and ORF3 Proteins of Hepatitis E VirusJournal of Virology, 80
Toshinori Tanaka, Masaharu Takahashi, E. Kusano, H. Okamoto (2007)
Development and evaluation of an efficient cell-culture system for Hepatitis E virus.The Journal of general virology, 88 Pt 3
Ling Lu, Chunhua Li, C. Hagedorn (2006)
Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosisReviews in Medical Virology, 16
M Takahashi, T Nishizawa, T Tanaka, B Tsatsralt-Od, J Inoue, H Okamoto (2005)
Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in JapanJ Gen Virol, 86
Tom Moritz, W. Duckworth, C. Abraira (2009)
Persistent Carriage of Hepatitis E Virus in Patients with HIV Infection
Kentaro Yamada, Masaharu Takahashi, Y. Hoshino, Hideyuki Takahashi, K. Ichiyama, S. Nagashima, Toshinori Tanaka, H. Okamoto (2009)
ORF3 protein of hepatitis E virus is essential for virion release from infected cells.The Journal of general virology, 90 Pt 8
Masaharu Takahashi, Kentaro Yamada, Y. Hoshino, Hideyuki Takahashi, K. Ichiyama, Toshinori Tanaka, H. Okamoto (2008)
Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in fecesArchives of Virology, 153
Masaharu Takahashi, T. Nishizawa, Haruko Miyajima, Y. Gotanda, Teruhiko Iita, F. Tsuda, H. Okamoto (2003)
Swine hepatitis E virus strains in Japan form four phylogenetic clusters comparable with those of Japanese isolates of human hepatitis E virus.The Journal of general virology, 84 Pt 4
Yukihiro Sato, Hiroyuki Sato, Keisuke Naka, S. Furuya, Haruhisa Tsukiji, Koji Kitagawa, Y. Sonoda, Takanobu Usui, H. Sakamoto, S. Yoshino, Y. Shimizu, Masaharu Takahashi, S. Nagashima, Jirintai, T. Nishizawa, H. Okamoto (2011)
A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypesArchives of Virology, 156
V. Arankalle, L. Chobe, M. Chadha (2006)
Type‐IV Indian swine HEV infects rhesus monkeysJournal of Viral Hepatitis, 13
Masaharu Takahashi, Toshinori Tanaka, Hideyuki Takahashi, Y. Hoshino, S. Nagashima, Jirintai, H. Mizuo, Y. Yazaki, T. Takagi, M. Azuma, E. Kusano, N. Isoda, K. Sugano, H. Okamoto (2010)
Hepatitis E Virus (HEV) Strains in Serum Samples Can Replicate Efficiently in Cultured Cells Despite the Coexistence of HEV Antibodies: Characterization of HEV Virions in Blood CirculationJournal of Clinical Microbiology, 48
E. Domingo, V. Martín, C. Perales, A. Grande-Pérez, J. García-Arriaza, A. Arias (2006)
Viruses as Quasispecies: Biological ImplicationsQuasispecies: Concept and Implications for Virology, 299
Hideto Sonoda, M. Abe, Takeshi Sugimoto, Yukihiro Sato, M. Bando, E. Fukui, H. Mizuo, Masaharu Takahashi, T. Nishizawa, H. Okamoto (2004)
Prevalence of Hepatitis E Virus (HEV) Infection in Wild Boars and Deer and Genetic Identification of a Genotype 3 HEV from a Boar in JapanJournal of Clinical Microbiology, 42
J. Thompson, D. Higgins, T. Gibson (1994)
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.Nucleic acids research, 22 22
E. Haagsma, H. Niesters, A. Berg, A. Riezebos‐Brilman, R. Porte, H. Vennema, J. Reimerink, M. Koopmans (2009)
Prevalence of hepatitis E virus infection in liver transplant recipientsLiver Transplantation, 15
Masaharu Takahashi, T. Nishizawa, Toshinori Tanaka, B. Tsatsralt‐Od, J. Inoue, H. Okamoto (2005)
Short Communication Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan
P. Shukla, Hanh Nguyen, U. Torian, R. Engle, K. Faulk, H. Dalton, R. Bendall, F. Keane, R. Purcell, S. Emerson (2011)
Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus–host recombinantProceedings of the National Academy of Sciences, 108
M.S. Balayart, A. Andjaparidze, S. Savinskaya, E. Ketiladze, D. Braginsky, A. Savinov, V. Poleschuk (1983)
Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route.Intervirology, 20 1
AR Feagins, T Opriessnig, DK Guenette, PG Halbur, XJ Meng (2007)
Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USAJ Gen Virol, 88
A. Tam, Matthew Smith, M. Guerra, Chiao-Chain Huang, D. Bradley, K. Fry, G. Reyes (1991)
Hepatitis E virus (HEV): Molecular cloning and sequencing of the full-length viral genomeVirology, 185
K. Tamura, D. Peterson, N. Peterson, G. Stecher, M. Nei, Sudhir Kumar (2011)
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.Molecular biology and evolution, 28 10
Kentaro Yamada, Masaharu Takahashi, Y. Hoshino, Hideyuki Takahashi, K. Ichiyama, Toshinori Tanaka, H. Okamoto (2009)
Construction of an infectious cDNA clone of hepatitis E virus strain JE03-1760F that can propagate efficiently in cultured cells.The Journal of general virology, 90 Pt 2
Vivek Chandra, Shikha Taneja, Manjula Kalia, S. Jameel (1999)
Molecular biology and pathogenesis of hepatitis E virusJournal of Biosciences, 33
S. Ijaz, E. Arnold, M. Banks, R. Bendall, M. Cramp, R. Cunningham, H. Dalton, T. Harrison, S. Hill, L. Macfarlane, R. Meigh, S. Shafi, M. Sheppard, J. Smithson, M.P. Wilson, C. Teo (2005)
Non-travel-associated hepatitis E in England and Wales: demographic, clinical, and molecular epidemiological characteristics.The Journal of infectious diseases, 192 7
Alicia Feagins, T. Opriessnig, D. Guenette, P. Halbur (2007)
Short Communication Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USA
SU Emerson, D Anderson, A Arankalle, XJ Meng, M Purdy, GG Schlauder, SA Tsarev (2005)
Virus taxonomy
Tiancheng Li, K. Chijiwa, N. Sera, T. Ishibashi, Yoshiki Etoh, Y. Shinohara, Yasuo Kurata, Miki Ishida, Shigeru Sakamoto, N. Takeda, T. Miyamura (2005)
Hepatitis E Virus Transmission from Wild Boar MeatEmerging Infectious Diseases, 11
H. Mizuo, Kazuyuki Suzuki, Y. Takikawa, Y. Sugai, H. Tokita, Y. Akahane, K. Itoh, Y. Gotanda, Masaharu Takahashi, T. Nishizawa, H. Okamoto (2002)
Polyphyletic Strains of Hepatitis E Virus Are Responsible for Sporadic Cases of Acute Hepatitis in JapanJournal of Clinical Microbiology, 40
SU Emerson, RH Purcell (2007)
Fields Virology
H. Okamoto (2007)
Genetic variability and evolution of hepatitis E virus.Virus research, 127 2
Recent evidence has indicated the cross-species transmission of hepatitis E virus (HEV) from pigs and wild boars to humans, causing zoonosis, mostly via consumption of uncooked or undercooked animal meat/viscera. However, no efficient cell culture system for swine and boar HEV strains has been established. We inoculated A549 cells with 12 swine and boar HEV strains of liver, feces, or serum origin at an HEV load of ≥2.0 × 10 4 copies per well and found that the HEV progeny replicated as efficiently as human HEV strains, with a maximum load of ~10 8 copies/ml. However, the HEV load in the culture medium at 30 days post-inoculation differed markedly by inoculum, ranging from 1.0 × 10 2 to 1.1 × 10 7 copies/ml upon inoculation at a lower load of approximately 10 5 copies per well. All progeny were passaged successfully onto A549 and PLC/PRF/5 cells. In sharp contrast, no progeny viruses were detectable in the culture supernatant upon inoculation with 13 swine and boar HEV strains at an HEV load of <1.8 × 10 4 copies per well. The present study also demonstrates that swine liver sold as food can be infectious, supporting the risk of zoonotic food-borne HEV infection.
Archives of Virology – Springer Journals
Published: Feb 1, 2012
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