Mammalian Genome 10, 649–652 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 A YAC contig encompassing the 11q14.3 breakpoint of a translocation associated with schizophrenia, and including the tyrosinase gene Joe ¨lle Petit, Pierre Boisseau, Laurence Taine, Bruno Gauthier, Benoit Arveiler Laboratoire de Pathologie Mole ´culaire et The ´rapie Ge ´nique, Universite ´ Victor Segalen Bordeaux 2, 146 rue Le ´o Saignat, 33076 Bordeaux Cedex, France Received: 23 September 1998 / Accepted: 31 January 1999 A balanced translocation t(1,11)(q42.1–q14.3) associated with played by both the derivative 1 and derivative 11 Chrs of a t(1,11) schizophrenia in a Scottish family has been described (St Clair et translocation carrier. al. 1990). It is assumed that a gene(s) responsible for the suscep- A 3-Mb contig spanning mainly the region immediately distal tibility to the disease is located in 1q42.1 or in 11q14.3 and is to the translocation breakpoint was established in a previous study either broken by the translocation or has its expression altered by (Evans et al. 1995a). One YAC (D0485) spanned the breakpoint. a position effect. A further possibility is that schizophrenia is Based upon a number of markers analyzed in common, this contig caused by a mutation
Mammalian Genome – Springer Journals
Published: Mar 11, 2014
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