A valveless capillary mixing system using a novel approach for passive flow control

A valveless capillary mixing system using a novel approach for passive flow control Using capillary-driven forces as a means to pump and actuate fluids is attractive for many applications including portable, lab-on-a-chip diagnostic systems. However, the lack of reliable and easy-to-integrate means of flow control remains a major challenge for implementing more complex bioassays using capillary microfluidics. This paper presents an easy-to-fabricate, valveless capillary system allowing for high-reliability flow control without using traditional capillary stop or trigger valves. Analytical calculations were used to deduce a design criterion for flow control in the valveless system. Furthermore, electrical analogy modeling was used to analyze and optimize the flow characteristics in the valveless system. Silicon-based test structures and capillary mixing systems were fabricated to check the design criterion and benchmark the electrical analogy model, respectively. Experimental results were in good agreement for the analytically derived flow control criterion. Experimental measurements of the liquid–vapor interface position with respect to time agreed well with the electrical analogy modeling results. The flow control scheme developed in the work provides designers with another means to realize complex fluid processing requirements without the need for traditional valve structures. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Microfluids and Nanofluids Springer Journals

A valveless capillary mixing system using a novel approach for passive flow control

Loading next page...
 
/lp/springer_journal/a-valveless-capillary-mixing-system-using-a-novel-approach-for-passive-SICk2VHj8Y
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Engineering; Engineering Fluid Dynamics; Biomedical Engineering; Analytical Chemistry; Nanotechnology and Microengineering
ISSN
1613-4982
eISSN
1613-4990
D.O.I.
10.1007/s10404-017-1981-9
Publisher site
See Article on Publisher Site

Abstract

Using capillary-driven forces as a means to pump and actuate fluids is attractive for many applications including portable, lab-on-a-chip diagnostic systems. However, the lack of reliable and easy-to-integrate means of flow control remains a major challenge for implementing more complex bioassays using capillary microfluidics. This paper presents an easy-to-fabricate, valveless capillary system allowing for high-reliability flow control without using traditional capillary stop or trigger valves. Analytical calculations were used to deduce a design criterion for flow control in the valveless system. Furthermore, electrical analogy modeling was used to analyze and optimize the flow characteristics in the valveless system. Silicon-based test structures and capillary mixing systems were fabricated to check the design criterion and benchmark the electrical analogy model, respectively. Experimental results were in good agreement for the analytically derived flow control criterion. Experimental measurements of the liquid–vapor interface position with respect to time agreed well with the electrical analogy modeling results. The flow control scheme developed in the work provides designers with another means to realize complex fluid processing requirements without the need for traditional valve structures.

Journal

Microfluids and NanofluidsSpringer Journals

Published: Aug 11, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off