A standard diabetic rat model for muscle flap studies

A standard diabetic rat model for muscle flap studies There are numerous experimental studies using rats that investigate diabetic muscle flaps and vascular pathology. The aim of this study was to develop and present a standard diabetic rat model for muscle flap studies via examining the time-dependent histological alterations of the rectus abdominis muscle vascular structure. Experimental diabetes was introduced in 15 male adult Sprague–Dawley rats by injecting a single dose of intraperitoneal streptozotocin (STZ) (60 mg/kg). The control group of five rats received a single intraperitoneal injection of 1 cm 3 sterile saline. Starting at the 15th day from the time of injection, random single rats from each group were sacrificed at 15-day intervals. Rectus abdominis musculocutaneous flaps were harvested and evaluated histopathologically. Endothelial irregularity and fragmentation started by the 30th day. All of these morphologic alterations became more evident as the duration of diabetes extended. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

A standard diabetic rat model for muscle flap studies

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Publisher
Springer-Verlag
Copyright
Copyright © 2005 by Springer-Verlag
Subject
Medicine
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-005-0793-4
Publisher site
See Article on Publisher Site

Abstract

There are numerous experimental studies using rats that investigate diabetic muscle flaps and vascular pathology. The aim of this study was to develop and present a standard diabetic rat model for muscle flap studies via examining the time-dependent histological alterations of the rectus abdominis muscle vascular structure. Experimental diabetes was introduced in 15 male adult Sprague–Dawley rats by injecting a single dose of intraperitoneal streptozotocin (STZ) (60 mg/kg). The control group of five rats received a single intraperitoneal injection of 1 cm 3 sterile saline. Starting at the 15th day from the time of injection, random single rats from each group were sacrificed at 15-day intervals. Rectus abdominis musculocutaneous flaps were harvested and evaluated histopathologically. Endothelial irregularity and fragmentation started by the 30th day. All of these morphologic alterations became more evident as the duration of diabetes extended.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Jan 1, 2006

References

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