A Spatial Registration Toolbox for Structural MR Imaging of the Aging Brain

A Spatial Registration Toolbox for Structural MR Imaging of the Aging Brain During aging the brain undergoes a series of structural changes, in size, shape as well as tissue composition. In particular, cortical atrophy and ventricular enlargement are often present in the brain of elderly individuals. This poses serious challenges in the spatial registration of structural MR images. In this study, we addressed this open issue by proposing an enhanced framework for MR registration and segmentation. Our solution was compared with other approaches based on the tools available in SPM12, a widely used software package. Performance of the different methods was assessed on 229 T1-weighted images collected in healthy individuals, with age ranging between 55 and 90 years old. Our method showed a consistent improvement as compared to other solutions, especially for subjects with enlarged lateral ventricles. It also provided a superior inter-subject alignment in cortical regions, with the most marked improvement in the frontal lobe. We conclude that our method is a valid alternative to standard approaches based on SPM12, and is particularly suitable for the processing of structural MR images of brains with cortical atrophy and ventricular enlargement. The method is integrated in our software toolbox MRTool, which is freely available to the scientific community. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroinformatics Springer Journals

A Spatial Registration Toolbox for Structural MR Imaging of the Aging Brain

Loading next page...
 
/lp/springer_journal/a-spatial-registration-toolbox-for-structural-mr-imaging-of-the-aging-6hYROgFBbZ
Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Neurosciences; Bioinformatics; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Neurology
ISSN
1539-2791
eISSN
1559-0089
D.O.I.
10.1007/s12021-018-9355-3
Publisher site
See Article on Publisher Site

Abstract

During aging the brain undergoes a series of structural changes, in size, shape as well as tissue composition. In particular, cortical atrophy and ventricular enlargement are often present in the brain of elderly individuals. This poses serious challenges in the spatial registration of structural MR images. In this study, we addressed this open issue by proposing an enhanced framework for MR registration and segmentation. Our solution was compared with other approaches based on the tools available in SPM12, a widely used software package. Performance of the different methods was assessed on 229 T1-weighted images collected in healthy individuals, with age ranging between 55 and 90 years old. Our method showed a consistent improvement as compared to other solutions, especially for subjects with enlarged lateral ventricles. It also provided a superior inter-subject alignment in cortical regions, with the most marked improvement in the frontal lobe. We conclude that our method is a valid alternative to standard approaches based on SPM12, and is particularly suitable for the processing of structural MR images of brains with cortical atrophy and ventricular enlargement. The method is integrated in our software toolbox MRTool, which is freely available to the scientific community.

Journal

NeuroinformaticsSpringer Journals

Published: Jan 19, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off