Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A snapshot of lipid levels in the Republic of Ireland in 2017

A snapshot of lipid levels in the Republic of Ireland in 2017 Background Abnormalities in blood lipid levels are causally linked with cardiovascular disease and pancreatitis. Data is limited regarding lipid abnormalities in Ireland. Aims As part of a cholesterol awareness campaign, we performed a pilot study of current lipid levels to preliminarily assess the extent and pattern of lipid abnormalities in Ireland. Methods Non-fasting, full lipid profiles and glucose measurements were performed in 259 people (32 on lipid-lowering med- ication and 225 untreated) using a validated Cholestech LDX machine. Untreated participants included 95 men and 130 women, aged 51 ± 16 years. Results The mean ± SD, total, low-density lipoprotein (LDL), high-density lipoprotein cholesterol (HDL) and median(IQR) non- HDL cholesterol and triglyceride levels in untreated individuals were 5.0 ± 1.1, 2.8 ± 1.0, 1.5 ± 0.5 and 3.4 (2.8–4.3), 1.6 (1.0–2.3) mmol/l respectively. Glucose was 5.3 (4.8–5.8) mmol/l. Glucose > 7.8 mmol/l occurred in 10 individuals (4%). Using defined criteria for non-fasting lipid levels, 60% of participants had some form of lipid abnormality with a frequency of 47% having a total cholesterol > 5, 35% with LDL > 3.0, 26% with HDL < 1.0/1.2, 33% with triglycerides > 2.0 and 32% with non-HDL cholesterol > 3.9 mmol/l. Three individuals had http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Irish Journal of Medical Science (1971 -) Springer Journals

A snapshot of lipid levels in the Republic of Ireland in 2017

Download PDF
7 pages

Loading next page...
 
/lp/springer_journal/a-snapshot-of-lipid-levels-in-the-republic-of-ireland-in-2017-QblPYTm3G7
Publisher
Springer Journals
Copyright
Copyright © 2018 by Royal Academy of Medicine in Ireland
Subject
Medicine & Public Health; Internal Medicine; General Practice / Family Medicine
ISSN
0021-1265
eISSN
1863-4362
DOI
10.1007/s11845-018-1820-3
Publisher site
See Article on Publisher Site

Abstract

Background Abnormalities in blood lipid levels are causally linked with cardiovascular disease and pancreatitis. Data is limited regarding lipid abnormalities in Ireland. Aims As part of a cholesterol awareness campaign, we performed a pilot study of current lipid levels to preliminarily assess the extent and pattern of lipid abnormalities in Ireland. Methods Non-fasting, full lipid profiles and glucose measurements were performed in 259 people (32 on lipid-lowering med- ication and 225 untreated) using a validated Cholestech LDX machine. Untreated participants included 95 men and 130 women, aged 51 ± 16 years. Results The mean ± SD, total, low-density lipoprotein (LDL), high-density lipoprotein cholesterol (HDL) and median(IQR) non- HDL cholesterol and triglyceride levels in untreated individuals were 5.0 ± 1.1, 2.8 ± 1.0, 1.5 ± 0.5 and 3.4 (2.8–4.3), 1.6 (1.0–2.3) mmol/l respectively. Glucose was 5.3 (4.8–5.8) mmol/l. Glucose > 7.8 mmol/l occurred in 10 individuals (4%). Using defined criteria for non-fasting lipid levels, 60% of participants had some form of lipid abnormality with a frequency of 47% having a total cholesterol > 5, 35% with LDL > 3.0, 26% with HDL < 1.0/1.2, 33% with triglycerides > 2.0 and 32% with non-HDL cholesterol > 3.9 mmol/l. Three individuals had

Journal

Irish Journal of Medical Science (1971 -) – Springer Journals

Published: Jun 1, 2018

References

  • Low-density lipoproteins cause atherosclerotic cardiovascular disease. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel
    Ference, BA; Ginsberg, HN; Graham, I; Ray, KK; Packard, CJ; Bruckert, E; Hegele, RA; Krauss, RM; Raal, FJ; Schunkert, H; Watts, GF; Borén, J; Fazio, S; Horton, JD; Masana, L; Nicholls, SJ; Nordestgaard, BG; van de Sluis, B; Taskinen, MR; Tokgözoğlu, L; Landmesser, U; Laufs, U; Wiklund, O; Stock, JK; Chapman, MJ; Catapano, AL
  • Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline
    Berglund, L; Brunzell, JD; Goldberg, AC; Goldberg, IJ; Sacks, F; Murad, MH; Stalenhoef, AF
  • Serum triglycerides and risk of cardiovascular disease
    Boullart, AC; Graaf, J; Stalenhoef, AF
  • Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
    Chapman, MJ; Ginsberg, HN; Amarenco, P; Andreotti, F; Borén, J; Catapano, AL; Descamps, OS; Fisher, E; Kovanen, PT; Kuivenhoven, JA; Lesnik, P; Masana, L; Nordestgaard, BG; Ray, KK; Reiner, Z; Taskinen, MR; Tokgözoglu, L; Tybjærg-Hansen, A; Watts, GF
  • Nonfasting triglycerides and risk of ischemic stroke in the general population
    Freiberg, JJ; Tybjaerg-Hansen, A; Jensen, JS; Nordestgaard, BG
  • Remnant cholesterol as a causal risk factor for ischemic heart disease
    Varbo, A; Benn, M; Tybjærg-Hansen, A; Jørgensen, AB; Frikke-Schmidt, R; Nordestgaard, BG
  • Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies
    Hokanson, JE; Austin, MA
  • Hyperlipidaemic pancreatitis
    Toskes, PP
  • Plasma HDL cholesterol and risk of myocardial infarction: a Mendelian randomisation study
    Voight, BF; Peloso, GM; Orho-Melander, M; Frikke-Schmidt, R; Barbalic, M; Jensen, MK; Hindy, G; Hólm, H; Ding, EL; Johnson, T; Schunkert, H; Samani, NJ; Clarke, R; Hopewell, JC; Thompson, JF; Li, M; Thorleifsson, G; Newton-Cheh, C; Musunuru, K; Pirruccello, JP; Saleheen, D; Chen, L; Stewart, AFR; Schillert, A; Thorsteinsdottir, U; Thorgeirsson, G; Anand, S; Engert, JC; Morgan, T; Spertus, J; Stoll, M; Berger, K; Martinelli, N; Girelli, D; McKeown, PP; Patterson, CC; Epstein, SE; Devaney, J; Burnett, MS; Mooser, V; Ripatti, S; Surakka, I; Nieminen, MS; Sinisalo, J; Lokki, ML; Perola, M; Havulinna, A; de Faire, U; Gigante, B; Ingelsson, E; Zeller, T; Wild, P; de Bakker, PIW; Klungel, OH; Maitland-van der Zee, AH; Peters, BJM; de Boer, A; Grobbee, DE; Kamphuisen, PW; Deneer, VHM; Elbers, CC; Onland-Moret, NC; Hofker, MH; Wijmenga, C; Verschuren, WMM; Boer, JMA; van der Schouw, YT; Rasheed, A; Frossard, P; Demissie, S; Willer, C; Do, R; Ordovas, JM; Abecasis, GR; Boehnke, M; Mohlke, KL; Daly, MJ; Guiducci, C; Burtt, NP; Surti, A; Gonzalez, E; Purcell, S; Gabriel, S; Marrugat, J; Peden, J; Erdmann, J; Diemert, P; Willenborg, C; König, IR; Fischer, M; Hengstenberg, C; Ziegler, A; Buysschaert, I; Lambrechts, D; van de Werf, F; Fox, KA; el Mokhtari, NE; Rubin, D; Schrezenmeir, J; Schreiber, S; Schäfer, A; Danesh, J; Blankenberg, S; Roberts, R; McPherson, R; Watkins, H; Hall, AS; Overvad, K; Rimm, E; Boerwinkle, E; Tybjaerg-Hansen, A; Cupples, LA; Reilly, MP; Melander, O; Mannucci, PM; Ardissino, D; Siscovick, D; Elosua, R; Stefansson, K; O'Donnell, CJ; Salomaa, V; Rader, DJ; Peltonen, L; Schwartz, SM; Altshuler, D; Kathiresan, S
  • Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
    Khera, AV; Cuchel, M; Llera-Moya, M
  • Cardiovascular risk factor changes in the Kilkenny Health Project: a community health promotion programme
    Shelley, E; Daly, L; Collins, C; Christie, M; Conroy, R; Gibney, M; Hickey, N; Kelleher, C; Kilcoyne, D; Lee, P
  • Failure to control hypercholesterolaemia in the Irish adult population: cross-sectional analysis of the baseline wave of The Irish Longitudinal Study on Ageing (TILDA)
    Murphy, C; Shelley, E; O'Halloran, AM; Fahey, T; Kenny, RA
  • National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3.0 million participants
    Farzadfar, F; Finucane, MM; Danaei, G; Pelizzari, PM; Cowan, MJ; Paciorek, CJ; Singh, GM; Lin, JK; Stevens, GA; Riley, LM; Ezzati, M
  • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    Friedewald, WT; Levy, RI; Fredrickson, DS
  • European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Joint Consensus Initiative. Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints-A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine
    Nordestgaard, BG; Langsted, A; Mora, S; Kolovou, G; Baum, H; Bruckert, E; Watts, GF; Sypniewska, G; Wiklund, O; Boren, J; Chapman, MJ; Cobbaert, C; Descamps, OS; von Eckardstein, A; Kamstrup, PR; Pulkki, K; Kronenberg, F; Remaley, AT; Rifai, N; Ros, E; Langlois, M
  • Trends in lipids and lipoproteins in US adults, 1988–2010
    Carroll, MD; Kit, BK; Lacher, DA; Shero, ST; Mussolino, ME
  • Prevalence and correlates of diagnosed and undiagnosed type 2 diabetes mellitus and pre-diabetes in older adults: findings from the Irish Longitudinal Study on Ageing (TILDA)
    Leahy, S; O’Halloran, A; O’Leary, N; Healy, M; McCormack, M; Kenny, R; O’Connell, J
  • Small dense low-density lipoprotein and its role as an independent predictor of cardiovascular disease
    Packard, CJ
  • Statin use in adults at high risk of cardiovascular disease mortality: cross-sectional analysis of baseline data from The Irish Longitudinal Study on Ageing (TILDA)
    Murphy, C; Bennett, K; Fahey, T; Shelley, E; Graham, I; Kenny, RA
  • A report from the European Society of Cardiology European Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) IV cross-sectional survey in 14 European regions
    Kotseva, K; Bacquer, D; Backer, G
  • Lipid targets in clinical practice: successes, failures and lessons to be learned
    Dunne, M; MacAnaney, O; Markham, C; Maher, V
  • Does the presence of the 3500 mutant apolipoprotein B-100 in low density lipoprotein particles affect their atherogenicity?
    Maher, V; Gallagher, J; Thompson, G; Myant, N
  • Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia
    Khera, AV; Won, HH; Peloso, GM; Lawson, KS; Bartz, TM; Deng, X; van Leeuwen, EM; Natarajan, P; Emdin, CA; Bick, AG; Morrison, AC; Brody, JA; Gupta, N; Nomura, A; Kessler, T; Duga, S; Bis, JC; van Duijn, CM; Cupples, LA; Psaty, B; Rader, DJ; Danesh, J; Schunkert, H; McPherson, R; Farrall, M; Watkins, H; Lander, E; Wilson, JG; Correa, A; Boerwinkle, E; Merlini, PA; Ardissino, D; Saleheen, D; Gabriel, S; Kathiresan, S