A skin tumor as a marker for a hereditary cancer syndrome: Muir-Torre syndrome

A skin tumor as a marker for a hereditary cancer syndrome: Muir-Torre syndrome If after excision of a skin tumor, the diagnosis of the pathologist is an epithelioma, adenoma, or carcinoma of sebaceous origin, one should be alert for Muir-Torre syndrome (MTS). In its simplest description, this syndrome is the association of sebaceous gland neoplasm with internal malignancy in the same patient. The sebaceous gland tumor may precede, appear concurrently, or follow the diagnosis of the patients‘ internal malignancy. The sebaceous tumor occurs prior to or concurrent with an internal malignancy in 44% to 63% of the MTS patients ( 3 , 7 ). The sebaceous skin tumor can therefore be used as a marker for internal malignancies. This fact is important because internal malignancies in MTS tend to be less aggressive compared to sporadic malignancies. This article describes the incidence of MTS in a cohort of patients diagnosed as suffering from a sebaceous gland neoplasm, who visited our Department of Plastic and Reconstructive Surgery, in collaboration with the Department of Dermatology. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

A skin tumor as a marker for a hereditary cancer syndrome: Muir-Torre syndrome

Loading next page...
 
/lp/springer_journal/a-skin-tumor-as-a-marker-for-a-hereditary-cancer-syndrome-muir-torre-JhRcvAppm0
Publisher
Springer-Verlag
Copyright
Copyright © 2005 by Springer-Verlag
Subject
Medicine
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-005-0766-7
Publisher site
See Article on Publisher Site

Abstract

If after excision of a skin tumor, the diagnosis of the pathologist is an epithelioma, adenoma, or carcinoma of sebaceous origin, one should be alert for Muir-Torre syndrome (MTS). In its simplest description, this syndrome is the association of sebaceous gland neoplasm with internal malignancy in the same patient. The sebaceous gland tumor may precede, appear concurrently, or follow the diagnosis of the patients‘ internal malignancy. The sebaceous tumor occurs prior to or concurrent with an internal malignancy in 44% to 63% of the MTS patients ( 3 , 7 ). The sebaceous skin tumor can therefore be used as a marker for internal malignancies. This fact is important because internal malignancies in MTS tend to be less aggressive compared to sporadic malignancies. This article describes the incidence of MTS in a cohort of patients diagnosed as suffering from a sebaceous gland neoplasm, who visited our Department of Plastic and Reconstructive Surgery, in collaboration with the Department of Dermatology.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Nov 1, 2005

References

  • MSH2 or MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis
    Wu, Y; Nystrom-Lahti, M; Osinga, J
  • Chronological ageing and photoageing of the human sebaceous gland
    Zouboulis, CC; Boschnakow, A

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off