A simple method for analysis of consecutive reactions with a second order formation and a first order decay of an intermediate

A simple method for analysis of consecutive reactions with a second order formation and a first... A simple method is developed to evaluate rate constants from absorbance-time traces for a pair of consecutive reactions consisting of a second order formation and a first order decay of an intermediate. Initially, a first order profile is simulated utilizing the data near the end of the reaction. The difference between this simulated and observed profiles provides the absorbance-time data for the initial phase from which a second order rate constant is evaluated. These rate constants were used to simulate composite kinetic curves which were then compared with experimental curves. This method was used to test the reaction between cis-Pt(NH3)2(H2O)2 2+ and a nonapeptide, ERFKCPCPT. The reaction proceeds through a cysteine coordinated intermediate formed in a second order process (first order with respect to each reactant). The intermediate is then converted to a product through a first order process, in which both cysteines are coordinated to platinum(II). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

A simple method for analysis of consecutive reactions with a second order formation and a first order decay of an intermediate

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Publisher
Springer Netherlands
Copyright
Copyright © 1997 by Springer
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1163/156856797X00268
Publisher site
See Article on Publisher Site

Abstract

A simple method is developed to evaluate rate constants from absorbance-time traces for a pair of consecutive reactions consisting of a second order formation and a first order decay of an intermediate. Initially, a first order profile is simulated utilizing the data near the end of the reaction. The difference between this simulated and observed profiles provides the absorbance-time data for the initial phase from which a second order rate constant is evaluated. These rate constants were used to simulate composite kinetic curves which were then compared with experimental curves. This method was used to test the reaction between cis-Pt(NH3)2(H2O)2 2+ and a nonapeptide, ERFKCPCPT. The reaction proceeds through a cysteine coordinated intermediate formed in a second order process (first order with respect to each reactant). The intermediate is then converted to a product through a first order process, in which both cysteines are coordinated to platinum(II).

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Apr 14, 2009

References

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