This work described a simple and efﬁcient method for the synthesis of some methylenebisamide derivatives. The reaction is carried out via a simple multi-component reaction between arylaldehydes, DMSO, and hydroxylamine hydrochloride. Short reaction times, excellent yields of products, inexpensive and readily available starting material, eco-friendly method, easy work-up, and high atom economy are the main advantages of this reaction. Graphical abstract H C CH 3 3 NH NH OH.HCl OH.HCl 2 2 O O Ar H H Ar O O H O/NaOH Ar N N Ar H H Keywords Bisamide Multi-component reaction DMSO Hydroxylamine hydrochloride One pot Introduction HT-29 colon cancer cell line, and on a panel of human cancer cell lines [7, 8]. In addition, some of them are used Amides, an important class of organic compounds, are of as inhibitors of the steroidal neuroprotective N-methyl-D- both natural and biological interest. They are part of a large aspartate receptors (NMDAR) . In particular, bisamides number of very important biomolecules and natural prod- are very important compounds. They are of remarkable ucts such as amino acids, polyamides, peptides, and pro- interest in the synthesis of peptidomimetic frameworks teins. Some amides have been reported to possess
Monatshefte für Chemie - Chemical Monthly – Springer Journals
Published: Dec 7, 2017
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