A simple and one-pot multi-component reaction to the synthesis of methylenebisamides

A simple and one-pot multi-component reaction to the synthesis of methylenebisamides This work described a simple and efficient method for the synthesis of some methylenebisamide derivatives. The reaction is carried out via a simple multi-component reaction between arylaldehydes, DMSO, and hydroxylamine hydrochloride. Short reaction times, excellent yields of products, inexpensive and readily available starting material, eco-friendly method, easy work-up, and high atom economy are the main advantages of this reaction. Graphical abstract H C CH 3 3 NH NH OH.HCl OH.HCl 2 2 O O Ar H H Ar O O H O/NaOH Ar N N Ar H H Keywords Bisamide  Multi-component reaction  DMSO  Hydroxylamine hydrochloride  One pot Introduction HT-29 colon cancer cell line, and on a panel of human cancer cell lines [7, 8]. In addition, some of them are used Amides, an important class of organic compounds, are of as inhibitors of the steroidal neuroprotective N-methyl-D- both natural and biological interest. They are part of a large aspartate receptors (NMDAR) [9]. In particular, bisamides number of very important biomolecules and natural prod- are very important compounds. They are of remarkable ucts such as amino acids, polyamides, peptides, and pro- interest in the synthesis of peptidomimetic frameworks teins. Some amides have been reported to possess http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Monatshefte für Chemie - Chemical Monthly Springer Journals

A simple and one-pot multi-component reaction to the synthesis of methylenebisamides

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Publisher
Springer Vienna
Copyright
Copyright © 2017 by Springer-Verlag GmbH Austria, part of Springer Nature
Subject
Chemistry; Chemistry/Food Science, general; Organic Chemistry; Inorganic Chemistry; Analytical Chemistry; Physical Chemistry; Theoretical and Computational Chemistry
ISSN
0026-9247
eISSN
1434-4475
D.O.I.
10.1007/s00706-017-2124-4
Publisher site
See Article on Publisher Site

Abstract

This work described a simple and efficient method for the synthesis of some methylenebisamide derivatives. The reaction is carried out via a simple multi-component reaction between arylaldehydes, DMSO, and hydroxylamine hydrochloride. Short reaction times, excellent yields of products, inexpensive and readily available starting material, eco-friendly method, easy work-up, and high atom economy are the main advantages of this reaction. Graphical abstract H C CH 3 3 NH NH OH.HCl OH.HCl 2 2 O O Ar H H Ar O O H O/NaOH Ar N N Ar H H Keywords Bisamide  Multi-component reaction  DMSO  Hydroxylamine hydrochloride  One pot Introduction HT-29 colon cancer cell line, and on a panel of human cancer cell lines [7, 8]. In addition, some of them are used Amides, an important class of organic compounds, are of as inhibitors of the steroidal neuroprotective N-methyl-D- both natural and biological interest. They are part of a large aspartate receptors (NMDAR) [9]. In particular, bisamides number of very important biomolecules and natural prod- are very important compounds. They are of remarkable ucts such as amino acids, polyamides, peptides, and pro- interest in the synthesis of peptidomimetic frameworks teins. Some amides have been reported to possess

Journal

Monatshefte für Chemie - Chemical MonthlySpringer Journals

Published: Dec 7, 2017

References

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