A Review of the Long-Term Efficacy, Tolerability, and Safety of Exenatide Once Weekly for Type 2 Diabetes

A Review of the Long-Term Efficacy, Tolerability, and Safety of Exenatide Once Weekly for Type 2... Adv Ther (2017) 34:1791–1814 DOI 10.1007/s12325-017-0499-6 REVIEW A Review of the Long-Term Efficacy, Tolerability, and Safety of Exenatide Once Weekly for Type 2 Diabetes . . Stefano Genovese Edoardo Mannucci Antonio Ceriello Received: March 22, 2016 / Published online: July 3, 2017 The Author(s) 2017. This article is an open access publication insulin glargine, as measured by HbA1c. In ABSTRACT drug-naı¨ve patients ExeOW was superior to sitagliptin and non-inferior to metformin, Introduction: Exenatide once weekly (ExeOW, whereas non-inferiority to pioglitazone and Bydureon , Astra Zeneca), a drug belonging to liraglutide was not proven. In different trials the class of glucagon-like peptide-1 (GLP-1) reductions in HbA1c ranged from -1.1% to receptor agonists, is the first agent approved for -2.0%. ExeOW therapy over 6 months was also treatment of type 2 diabetes (T2D) that can be associated with a mean weight loss of -2to administered on a weekly basis. -4 kg, improved systolic blood pressure and Methods: Data concerning treatment of T2D lipid profile, and no hypoglycemia unless asso- with ExeOW are reviewed with special reference ciated to sulfonylurea. ExeOW long-term ther- to its long-term efficacy, tolerability, and safety. apy up to 3–6 years allowed persistent glycemic Relevant literature was identified http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advances in Therapy Springer Journals

A Review of the Long-Term Efficacy, Tolerability, and Safety of Exenatide Once Weekly for Type 2 Diabetes

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Publisher
Springer Healthcare
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Internal Medicine; Oncology; Cardiology; Rheumatology; Endocrinology; Pharmacology/Toxicology
ISSN
0741-238X
eISSN
1865-8652
D.O.I.
10.1007/s12325-017-0499-6
Publisher site
See Article on Publisher Site

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