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A Review of the Current Evidence on Gadolinium Deposition in the Brain

A Review of the Current Evidence on Gadolinium Deposition in the Brain Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Klinische Neuroradiologie Springer Journals

A Review of the Current Evidence on Gadolinium Deposition in the Brain

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References (122)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Neuroradiology; Neurosurgery; Neurology
ISSN
0939-7116
eISSN
1869-1447
DOI
10.1007/s00062-018-0678-0
Publisher site
See Article on Publisher Site

Abstract

Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies.

Journal

Klinische NeuroradiologieSpringer Journals

Published: Mar 9, 2018

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