A Review of the Current Evidence on Gadolinium Deposition in the Brain

Richard Pullicino; Mark Radon; Shubhabrata Biswas; Maneesh Bhojak; Kumar Das

doi:10.1007/s00062-018-0678-0

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Publisher: Springer Journals
Copyright: Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject: Medicine & Public Health; Neuroradiology; Neurosurgery; Neurology
ISSN: 0939-7116
eISSN: 1869-1447
DOI: 10.1007/s00062-018-0678-0
Publisher site: See Article on Publisher Site

Abstract

Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies.

Journal

Klinische Neuroradiologie – Springer Journals

Published: Mar 9, 2018

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A Review of the Current Evidence on Gadolinium Deposition in the Brain

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A Review of the Current Evidence on Gadolinium Deposition in the Brain

A Review of the Current Evidence on Gadolinium Deposition in the Brain

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