Mammalian Genome 10, 1102–1105 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 1 1 1 1 2 2 Hossein Fakhrai-Rad, Hong Jiao, Luo-Sheng Li, Anna Glaser, George Koike, Howard J. Jacob, Holger 1 1 Luthman, Joakim Galli Karolinska Institute & CMM, Department of Molecular Medicine, Karolinska Hospital, L602, S-171 76 Stockholm, Sweden Medical College of Wisconsin, Department of Physiology, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA Received: 7 April 1999 / Accepted: 14 July 1999 Genetic heterogeneity in outbred populations and a major impact The linkage map was assembled by employing MAPMAKER/ of environmental factors on the disease phenotypes complicate EXP (version 3.0) linkage analysis software (Lander et al. 1987). genetic studies of multifactorial disorders. For control of these The 400 markers were sorted into 27 separate linkage groups with effects, inbred animal disease models are used for the genetic a LOD of 5.0 as inclusion criterion. All linkage groups were as- dissection of disease pathways that operate in concert to cause signed to specific chromosomes and oriented according to the rat susceptibility to several human common disorders. Quantitative cytogenetic map (Szpirer et al. 1998). All chromosomes except trait loci (QTLs) that contribute to disease phenotypes
Mammalian Genome – Springer Journals
Published: Nov 1, 1999
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