A Prospective Study to Evaluate the Feasibility and Outcome of Completing Concurrent Chemo-radiation and Brachytherapy Within 4Weeks Using Two Different Chemotherapy Regimens in Carcinoma Cervix

A Prospective Study to Evaluate the Feasibility and Outcome of Completing Concurrent... Purpose A prospective study was performed to assess the feasibility and outcome of completing concurrent chemo- radiotherapy (CCRT) in B 4 weeks in cervical cancer patients using combination of paclitaxel and cisplatin as weekly regimen versus weekly cisplatin as concurrent chemotherapy. Methods Forty patients of mostly locally advanced stage were prospectively allocated to receive either weekly cisplatin 2 2 2 (40 mg/m ) [arm A] or weekly paclitaxel (50 mg/m ) and cisplatin (30 mg/m ) [arm B]. External Beam Radiotherapy [EBRT] in both arms given was 45 Gy/20 fractions/5 fractions per week (using conventional technique, Co60 teletherapy), intracavitary radiotherapy 30 Gy to point A (using LDR in a single setting) in between EBRT fractions, starting after completion of 10 fractions of EBRT. Results Treatment of 65% of arm B and 70% of arm A patients could be completed by 4 weeks. At a median follow-up of 24 months, 85% patients in each arm had complete loco-regional control, on intention to treat analysis. Thirty-month survival in the respective arms were 69 and 72.2%. Grade 3 acute toxicity varied between 10 and 15% in both arms. Grade- 5 acute haematological toxicity was found in one patient (5%) of each arm. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Gynecologic Oncology Springer Journals

A Prospective Study to Evaluate the Feasibility and Outcome of Completing Concurrent Chemo-radiation and Brachytherapy Within 4Weeks Using Two Different Chemotherapy Regimens in Carcinoma Cervix

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Publisher
Springer India
Copyright
Copyright © 2018 by Association of Gynecologic Oncologists of India
Subject
Medicine & Public Health; Oncology; Surgical Oncology
ISSN
2363-8397
eISSN
2363-8400
D.O.I.
10.1007/s40944-018-0192-y
Publisher site
See Article on Publisher Site

Abstract

Purpose A prospective study was performed to assess the feasibility and outcome of completing concurrent chemo- radiotherapy (CCRT) in B 4 weeks in cervical cancer patients using combination of paclitaxel and cisplatin as weekly regimen versus weekly cisplatin as concurrent chemotherapy. Methods Forty patients of mostly locally advanced stage were prospectively allocated to receive either weekly cisplatin 2 2 2 (40 mg/m ) [arm A] or weekly paclitaxel (50 mg/m ) and cisplatin (30 mg/m ) [arm B]. External Beam Radiotherapy [EBRT] in both arms given was 45 Gy/20 fractions/5 fractions per week (using conventional technique, Co60 teletherapy), intracavitary radiotherapy 30 Gy to point A (using LDR in a single setting) in between EBRT fractions, starting after completion of 10 fractions of EBRT. Results Treatment of 65% of arm B and 70% of arm A patients could be completed by 4 weeks. At a median follow-up of 24 months, 85% patients in each arm had complete loco-regional control, on intention to treat analysis. Thirty-month survival in the respective arms were 69 and 72.2%. Grade 3 acute toxicity varied between 10 and 15% in both arms. Grade- 5 acute haematological toxicity was found in one patient (5%) of each arm.

Journal

Indian Journal of Gynecologic OncologySpringer Journals

Published: Mar 26, 2018

References

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