A practical and green protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using oxalic acid as organocatalyst

A practical and green protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using oxalic... NH NH Oxalic Acid NH OAc (20 mol%) Water:Ethanol CHO o CHO 80 C NH N O NH Keywords Multi-component reactions  Oxalic acid  2,3-Dihydroquinazolin- 4(1H)-ones  Green protocol & Vasant Helavi vbhelavi@gmail.com Department of Chemistry, Rajaram College, Kolhapur 416004, Maharashtra, India 123 3916 S. Karhale et al. Introduction The recent quest towards the implementation of green methodologies in synthetic chemistry has spurred an extensive interest in the multicomponent reactions (MCRs) for the generation of highly privileged scaffolds of molecular complexity [1]. Such methodologies are able to manage dual goals such as environmental protection, as well as economic benefit. The systematic improvements in such methodologies are challenging benchmarks to organic chemist, and hence desperate attempts have been made for the development of these methodologies [2, 3]. The MCRs show remarkable significance in construction of diverse and complex organic molecules in a single step, which includes all essential parts of the starting materials. Furthermore, MCRs also have additional merits such as its exceptional synthetic efficiency, high atom economy, decrease in waste generation and formation of essential carbon–carbon and carbon-heteroatom bonds [4–8]. MCRs using environmentally benign catalyst under mild reaction conditions in eco- friendly solvent have become fundamental strategy in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

A practical and green protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using oxalic acid as organocatalyst

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Springer Netherlands
Copyright © 2017 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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