A Patient-Specific Three-Dimensional Hemodynamic Model of the Circle of Willis

A Patient-Specific Three-Dimensional Hemodynamic Model of the Circle of Willis Circle of Willis (CoW) is one of the most important cerebral arteries in the human body and various attempts have been made to study the hemodynamic of blood flow in this vital part of the brain. In the present study, blood flow in a patient specific CoW is numerically modeled to predict disease-prone regions of the CoW. Medical images and computer aided design software are used to construct a realistic three-dimensional model of the CoW for this particular case. The arteries are considered as elastic conduits and the interactions between arterial walls and the blood flow are taken into account. Mooney-Rivlin hyperelastic model is used to describe the behavior of arterial walls and blood is considered as a non-Newtonian fluid obeying the Carreau model. An available experimental-based pulsatile velocity profile is used at the entrance of the CoW. The finite element-based commercial software, ADINA, is used to solve the governing equations. Blood pressure and velocity and arterial wall shear stress are calculated in different regions of the CoW. A simplified form of the model is also compared with the available published data. Results affirmed that the proposed computational model has the potential to capture the hemodynamic characteristics of the CoW. The computational results can be used to determine disease-prone locations for a given CoW. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiovascular Engineering and Technology Springer Journals

A Patient-Specific Three-Dimensional Hemodynamic Model of the Circle of Willis

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Publisher
Springer US
Copyright
Copyright © 2017 by Biomedical Engineering Society
Subject
Engineering; Biomedical Engineering; Cardiology; Biomedicine, general
ISSN
1869-408X
eISSN
1869-4098
D.O.I.
10.1007/s13239-017-0330-1
Publisher site
See Article on Publisher Site

Abstract

Circle of Willis (CoW) is one of the most important cerebral arteries in the human body and various attempts have been made to study the hemodynamic of blood flow in this vital part of the brain. In the present study, blood flow in a patient specific CoW is numerically modeled to predict disease-prone regions of the CoW. Medical images and computer aided design software are used to construct a realistic three-dimensional model of the CoW for this particular case. The arteries are considered as elastic conduits and the interactions between arterial walls and the blood flow are taken into account. Mooney-Rivlin hyperelastic model is used to describe the behavior of arterial walls and blood is considered as a non-Newtonian fluid obeying the Carreau model. An available experimental-based pulsatile velocity profile is used at the entrance of the CoW. The finite element-based commercial software, ADINA, is used to solve the governing equations. Blood pressure and velocity and arterial wall shear stress are calculated in different regions of the CoW. A simplified form of the model is also compared with the available published data. Results affirmed that the proposed computational model has the potential to capture the hemodynamic characteristics of the CoW. The computational results can be used to determine disease-prone locations for a given CoW.

Journal

Cardiovascular Engineering and TechnologySpringer Journals

Published: Sep 14, 2017

References

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