J. Med. Toxicol. (2017) 13:287–292 DOI 10.1007/s13181-017-0632-6 ORIGINAL ARTICLE A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in Oral Fluid After Reported Heroin Overdose 1 2 3 3 Matthew K. Griswold & Peter R. Chai & Alex J. Krotulski & Melissa Friscia & 1 4 2 3 Brittany P. Chapman & Neha Varma & Edward W. Boyer & Barry K. Logan & Kavita M. Babu Received: 23 May 2017 /Revised: 8 September 2017 /Accepted: 14 September 2017 /Published online: 2 October 2017 American College of Medical Toxicology 2017 Abstract and emerging drugs of abuse. Analytical instrumentation in- Introduction The adulteration of heroin with non- cluded SCIEX TripleTOF® 5600+ and Waters Xevo® G2-S pharmaceutical fentanyl and other high-potency opioids is QTOF systems. one of the factors contributing to striking increases in over- Results Thirty participants (N = 30) were enrolled during the dose deaths. To fully understand the magnitude of this prob- study period. Twenty-nine participants had fentanyl detected lem, accurate detection methods for fentanyl and other novel in their urine, while 27 had fentanyl identified in their oral opioid adulterant exposures are urgently required. The objec- fluid (overall agreement 93.3%, positive percent agreement
Journal of Medical Toxicology – Springer Journals
Published: Oct 2, 2017
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