A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in Oral Fluid After Reported Heroin Overdose

A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in... J. Med. Toxicol. (2017) 13:287–292 DOI 10.1007/s13181-017-0632-6 ORIGINAL ARTICLE A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in Oral Fluid After Reported Heroin Overdose 1 2 3 3 Matthew K. Griswold & Peter R. Chai & Alex J. Krotulski & Melissa Friscia & 1 4 2 3 Brittany P. Chapman & Neha Varma & Edward W. Boyer & Barry K. Logan & Kavita M. Babu Received: 23 May 2017 /Revised: 8 September 2017 /Accepted: 14 September 2017 /Published online: 2 October 2017 American College of Medical Toxicology 2017 Abstract and emerging drugs of abuse. Analytical instrumentation in- Introduction The adulteration of heroin with non- cluded SCIEX TripleTOF® 5600+ and Waters Xevo® G2-S pharmaceutical fentanyl and other high-potency opioids is QTOF systems. one of the factors contributing to striking increases in over- Results Thirty participants (N = 30) were enrolled during the dose deaths. To fully understand the magnitude of this prob- study period. Twenty-nine participants had fentanyl detected lem, accurate detection methods for fentanyl and other novel in their urine, while 27 had fentanyl identified in their oral opioid adulterant exposures are urgently required. The objec- fluid (overall agreement 93.3%, positive percent agreement http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Toxicology Springer Journals

A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in Oral Fluid After Reported Heroin Overdose

Loading next page...
 
/lp/springer_journal/a-novel-oral-fluid-assay-lc-qtof-ms-for-the-detection-of-fentanyl-and-lhzHEfE0AQ
Publisher
Springer US
Copyright
Copyright © 2017 by American College of Medical Toxicology
Subject
Biomedicine; Pharmacology/Toxicology; Biomedicine, general
ISSN
1556-9039
eISSN
1937-6995
D.O.I.
10.1007/s13181-017-0632-6
Publisher site
See Article on Publisher Site

Abstract

J. Med. Toxicol. (2017) 13:287–292 DOI 10.1007/s13181-017-0632-6 ORIGINAL ARTICLE A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in Oral Fluid After Reported Heroin Overdose 1 2 3 3 Matthew K. Griswold & Peter R. Chai & Alex J. Krotulski & Melissa Friscia & 1 4 2 3 Brittany P. Chapman & Neha Varma & Edward W. Boyer & Barry K. Logan & Kavita M. Babu Received: 23 May 2017 /Revised: 8 September 2017 /Accepted: 14 September 2017 /Published online: 2 October 2017 American College of Medical Toxicology 2017 Abstract and emerging drugs of abuse. Analytical instrumentation in- Introduction The adulteration of heroin with non- cluded SCIEX TripleTOF® 5600+ and Waters Xevo® G2-S pharmaceutical fentanyl and other high-potency opioids is QTOF systems. one of the factors contributing to striking increases in over- Results Thirty participants (N = 30) were enrolled during the dose deaths. To fully understand the magnitude of this prob- study period. Twenty-nine participants had fentanyl detected lem, accurate detection methods for fentanyl and other novel in their urine, while 27 had fentanyl identified in their oral opioid adulterant exposures are urgently required. The objec- fluid (overall agreement 93.3%, positive percent agreement

Journal

Journal of Medical ToxicologySpringer Journals

Published: Oct 2, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from Google Scholar, PubMed
Create lists to organize your research
Export lists, citations
Access to DeepDyve database
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off