A novel ENU-induced mutation, peewee, causes dwarfism in the mouse

A novel ENU-induced mutation, peewee, causes dwarfism in the mouse Mamm Genome (2009) 20:455 DOI 10.1007/s00335-009-9202-9 ERRATUM A novel ENU-induced mutation, peewee, causes dwarfism in the mouse Bokryeon Lee Æ Kiyoshi Kano Æ Jay Young Æ Simon WM. John Æ Patsy M. Nishina Æ Jurgen K. Naggert Æ Kunihiko Naito Published online: 30 July 2009 Springer Science+Business Media, LLC 2009 Abstract We identified a novel fertile autosomal reces- two introns, and an untranslated region of Slc10a4 did not sive mutation called peewee that results in dwarfing, in a find any sequence difference between the peewee mouse region-specific ENU-induced mutagenesis. These mice at and the C57BL/6 J mouse. Detailed analysis of peewee litter size were smaller those of other strains. Histological mice might provide novel molecular insights into the analysis revealed that the major organs appear normal, but complex mechanisms regulating body growth. abnormalities in cellular proliferation were observed in bone, liver, and testis. Haplotype analysis localized the peewee gene to a 3.3-Mb region between D5Mit83 and Erratum to: Mamm Genome DOI: 10.1007/s00335-009-9197-2 D5Mit356.3. There are 18 genes in this linkage area. We SM also performed in silico mapping using the PosMed In the above-mentioned article, published in this issue of program, which searches for connections among keywords Mammalian Genome, the corrected authors’ names are and genes in an interval, but no similar phenotype descriptions were found for these genes. In the peewee listed above. Citation of this article should read Lee et al. (2009) and mutant compared to the normal C57BL/6 J mouse, only Slc10a4 expression was lower. Our preliminary mutation not Bokryeon et al. (2009). analysis examining the nucleotide sequence of three exons, The online version of the original article can be found under doi: 10.1007/s00335-009-9197-2. B. Lee  K. Kano (&)  K. Naito Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan e-mail: akano@mail.ecc.u-tokyo.ac.jp J. Young  S. WM. John  P. M. Nishina  J. K. Naggert The Jackson Laboratory, Bar Harbor, ME 04609, USA http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

A novel ENU-induced mutation, peewee, causes dwarfism in the mouse

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Publisher
Springer-Verlag
Copyright
Copyright © 2009 by Springer Science+Business Media, LLC
Subject
Life Sciences; Zoology ; Anatomy ; Cell Biology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s00335-009-9202-9
Publisher site
See Article on Publisher Site

Abstract

Mamm Genome (2009) 20:455 DOI 10.1007/s00335-009-9202-9 ERRATUM A novel ENU-induced mutation, peewee, causes dwarfism in the mouse Bokryeon Lee Æ Kiyoshi Kano Æ Jay Young Æ Simon WM. John Æ Patsy M. Nishina Æ Jurgen K. Naggert Æ Kunihiko Naito Published online: 30 July 2009 Springer Science+Business Media, LLC 2009 Abstract We identified a novel fertile autosomal reces- two introns, and an untranslated region of Slc10a4 did not sive mutation called peewee that results in dwarfing, in a find any sequence difference between the peewee mouse region-specific ENU-induced mutagenesis. These mice at and the C57BL/6 J mouse. Detailed analysis of peewee litter size were smaller those of other strains. Histological mice might provide novel molecular insights into the analysis revealed that the major organs appear normal, but complex mechanisms regulating body growth. abnormalities in cellular proliferation were observed in bone, liver, and testis. Haplotype analysis localized the peewee gene to a 3.3-Mb region between D5Mit83 and Erratum to: Mamm Genome DOI: 10.1007/s00335-009-9197-2 D5Mit356.3. There are 18 genes in this linkage area. We SM also performed in silico mapping using the PosMed In the above-mentioned article, published in this issue of program, which searches for connections among keywords Mammalian Genome, the corrected authors’ names are and genes in an interval, but no similar phenotype descriptions were found for these genes. In the peewee listed above. Citation of this article should read Lee et al. (2009) and mutant compared to the normal C57BL/6 J mouse, only Slc10a4 expression was lower. Our preliminary mutation not Bokryeon et al. (2009). analysis examining the nucleotide sequence of three exons, The online version of the original article can be found under doi: 10.1007/s00335-009-9197-2. B. Lee  K. Kano (&)  K. Naito Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan e-mail: akano@mail.ecc.u-tokyo.ac.jp J. Young  S. WM. John  P. M. Nishina  J. K. Naggert The Jackson Laboratory, Bar Harbor, ME 04609, USA

Journal

Mammalian GenomeSpringer Journals

Published: Jul 30, 2009

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