A novel amino acid functionalized ionic liquid promoted one-pot solvent-free synthesis of 3,4-dihydropyrimidin-2-(1H)-thiones

A novel amino acid functionalized ionic liquid promoted one-pot solvent-free synthesis of... An environmentally benign, cheap and reusable L-amino acid functionalized ionic liquid [L-AAIL]/AlCl3 was found to be an effective catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-thione derivatives in good to excellent yield under solvent-free condition. Compared with the classical Biginelli reactions, this method consistently enjoys the advantages of mild reaction conditions, easy work-up, and short reaction time. These one-pot three-component Biginelli products could be separated easily from the catalyst–water system, and the catalyst could be reused at least five times without noticeably reducing catalytic activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

A novel amino acid functionalized ionic liquid promoted one-pot solvent-free synthesis of 3,4-dihydropyrimidin-2-(1H)-thiones

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Publisher
Springer Netherlands
Copyright
Copyright © 2012 by Springer Science+Business Media B.V.
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-012-0689-4
Publisher site
See Article on Publisher Site

Abstract

An environmentally benign, cheap and reusable L-amino acid functionalized ionic liquid [L-AAIL]/AlCl3 was found to be an effective catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-thione derivatives in good to excellent yield under solvent-free condition. Compared with the classical Biginelli reactions, this method consistently enjoys the advantages of mild reaction conditions, easy work-up, and short reaction time. These one-pot three-component Biginelli products could be separated easily from the catalyst–water system, and the catalyst could be reused at least five times without noticeably reducing catalytic activity.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jul 11, 2012

References

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