A novel 1,8-naphthalimide probe: synthesis and interactions with nucleic acid and its precursor
A novel 1,8-naphthalimide probe: synthesis and interactions with nucleic acid and its precursor
Li, He-Ting; Jiang, Zhi-Qin; Zheng, Juan; Wang, Xin; Pan, Yang; Wang, Feng; Yu, Shu-Qin
2006-01-01 00:00:00
Three novel, water-soluble N-substituted 1,8-naphthalimides as the spectroscopic probes of nucleic acid, N-(2-hydroxyethyl)-1,8-naphthalimide (NI1), 1,8-naphthalimide-N-acetic acid (NI2) and 1,8-naphthalimide-N-caproic acid (NI3), were synthesized and photophysically characterized. The steady-state fluorescence quenching of the NI probes with nucleic acids (NA) and their precursors (nucleobases and nucleosides) were studied by Stern–Volmer correlation. The rate constants for bimolecular quenching were obtained in Tris buffer solution. The transient absorption spectroscopy by nanosecond laser flash photolysis were explored to identify the transient species and to determine the kinetics. The dynamic interaction mechanism was attributed to electron transfer (ET) and energy transfer via
3NI.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngResearch on Chemical IntermediatesSpringer Journalshttp://www.deepdyve.com/lp/springer-journals/a-novel-1-8-naphthalimide-probe-synthesis-and-interactions-with-NwfkV70MVu
A novel 1,8-naphthalimide probe: synthesis and interactions with nucleic acid and its precursor
Three novel, water-soluble N-substituted 1,8-naphthalimides as the spectroscopic probes of nucleic acid, N-(2-hydroxyethyl)-1,8-naphthalimide (NI1), 1,8-naphthalimide-N-acetic acid (NI2) and 1,8-naphthalimide-N-caproic acid (NI3), were synthesized and photophysically characterized. The steady-state fluorescence quenching of the NI probes with nucleic acids (NA) and their precursors (nucleobases and nucleosides) were studied by Stern–Volmer correlation. The rate constants for bimolecular quenching were obtained in Tris buffer solution. The transient absorption spectroscopy by nanosecond laser flash photolysis were explored to identify the transient species and to determine the kinetics. The dynamic interaction mechanism was attributed to electron transfer (ET) and energy transfer via
3NI.
Journal
Research on Chemical Intermediates
– Springer Journals
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.