Curr Stem Cell Rep (2017) 3:149–155 DOI 10.1007/s40778-017-0084-6 IN VITRO AND IN VIVO MODELS IN STEM CELL BIOLOGY (E SCOTT, SECTION EDITOR) 1 1 1,2 2 1 P. Quesenberry & S. Wen & M. Dooner & G. Camussi & L. Goldberg Published online: 18 July 2017 Springer International Publishing AG 2017 Abstract considered within the context of transplant-based or normal Purpose of Review Our understanding of the biology of he- baseline hematopoiesis; they are quite distinct and likely have matopoietic stem cells is evolving beyond hierarchical models differential influences governing stem cell self-renewal and and markers of stem cell purification to a far more fluid model differentiation. Hematopoietic stem cell functions are further wherein degrees of multipotency of individual cells can modulated by interactions with a variety of extracellular ves- change over time. This review is to outline these new icles and influenced by circadian rhythms and other variables. concepts: Summary The true nature of the system remains to be defined, Recent Findings The long-term repopulating hematopoietic and such definition will elucidate the basic nature of stem cell stem cell is a proliferating cell, which is continually changing biology and indicate specifics of clinical relevance. in phenotype. It cannot
Current Stem Cell Reports – Springer Journals
Published: Jul 18, 2017
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