Short Communications 9 Springer-Verlag New York Inc. 1997 Mammalian Genome 8, 932-933 (1997). Petra Bilinski, John Schimenti, Achim Gossler The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA Received: ll April 1997 / Accepted: 18 August 1997 A number of spontaneous or radiation-induced deletions in the the phenotype, suggesting that homozygous Del(17)T 7J embryos proximal regions of mouse Chromosome (Chr) 17 including the die. Considering the similar phenotypes and genetics of Del(17)T 7s brachyury (T) gene have been identified on the basis of the con- and brachyury, we tested whether Del(17)T 7J is a new allele of spicuous tail phenotypes caused by loss-of-T function (for ex- brachyury. We intercrossed mice carrying T and tufted (T 07++) ample, Selby 1973; Johnson 1974; Babiarz 1983; Beddington et al. (Lyon 1956) with heterozygous Del(17)T 7J mice and analyzed 1992; Herrmann and Kispert 1994). Recently, additional nested embryos at d 9.5 of embryonic development for the presence of the deletions were specifically induced in this region of the genome by brachyury phenotype. Out of 39 embryos analyzed, 10 (26%) irradiation of ES cells (You et al. 1997). Such deletions have showed a phenotype that was indistinguishable from the phenotype proven valuable
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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