Acta Neurochir (2017) 159:1747–1756 DOI 10.1007/s00701-017-3244-7 ORIGINAL ARTICLE - BRAIN INJURY A new model for biofilm formation and inflammatory tissue reaction: intraoperative infection of a cranial implant with Staphylococcus aureus in rats 1 2 3 3 2 Silke Glage & Silke Paret & Andreas Winkel & Meike Stiesch & André Bleich & 2 2 Joachim K. Krauss & Kerstin Schwabe Received: 9 February 2017 /Accepted: 7 June 2017 /Published online: 25 June 2017 Springer-Verlag GmbH Austria 2017 Abstract implants on days 10 and 21 after surgery, while no bacteria Background Implant failure is a severe and frequent adverse were found in controls. This was accompanied by a substantial event in all areas of neurosurgery. It often involves infection inflammatory response of peri-implant tissue after infection, with biofilm formation, accompanied by inflammation of sur- also affecting the underlying brain tissue. rounding tissue, including the brain, and bone loss. The most Conclusions Intraoperative infection of implants with common bacteria involved are Staphylococcus aureus. We Staphylococcus aureus in rats may be useful as a tool to model here test whether intraoperative infection of intracranial new implant materials and surfaces on biofilm formation and screws with Staphylococcus aureus would lead to biofilm for-
Acta Neurochirurgica – Springer Journals
Published: Jun 25, 2017
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