A modified procedure for synthesis of the side chain of ceftazidime-activated thioester

A modified procedure for synthesis of the side chain of ceftazidime-activated thioester A modified procedure for synthesis of the side chain of ceftazidime-activated thioester has been established. This key intermediate of ceftazidime was obtained by a more eco-friendly process than conventional methods, and the yield was much higher (up to 92.4 %). It was found that different organic bases (triethylamine or pyridine) used in this reaction had different effects. The reaction conditions were also optimized to make the route more competitive and suitable for large-scale industrial production. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

A modified procedure for synthesis of the side chain of ceftazidime-activated thioester

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Publisher
Springer Netherlands
Copyright
Copyright © 2012 by Springer Science+Business Media B.V.
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-012-0583-0
Publisher site
See Article on Publisher Site

Abstract

A modified procedure for synthesis of the side chain of ceftazidime-activated thioester has been established. This key intermediate of ceftazidime was obtained by a more eco-friendly process than conventional methods, and the yield was much higher (up to 92.4 %). It was found that different organic bases (triethylamine or pyridine) used in this reaction had different effects. The reaction conditions were also optimized to make the route more competitive and suitable for large-scale industrial production.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: May 18, 2012

References

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