A Meta-analytic Review of Non-specific Effects in Randomized Controlled Trials of Cognitive Remediation for Schizophrenia

A Meta-analytic Review of Non-specific Effects in Randomized Controlled Trials of Cognitive... Cognitive remediation (CR) has been found to improve cognitive performance among adults with schizophrenia in randomized controlled trials (RCTs). However, improvements in cognitive performance are often observed in the control groups of RCTs as well. There has been no comprehensive examination of change in control groups for CR, which may inform trial methodology and improve our understanding of measured outcomes for cognitive remediation. In this meta-analysis, we calculated pre–post change in cognitive test performance within control groups of RCTs in 32 CR trials (n = 794 participants) published between 1970 and 2011, and examined the association between pre–post change and sample size, duration of treatment, type of control group, and participants’ age, intelligence, duration of illness, and psychiatric symptoms. Results showed that control groups in CR trials showed small effect size changes (Cohen’s d = 0.12 ± 0.16) in cognitive test performance over the trial duration. Study characteristics associated with pre–post change included participant age and sample size. These findings suggest attention to change in control groups may help improve detection of cognitive remediation effects for schizophrenia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychiatric Quarterly Springer Journals

A Meta-analytic Review of Non-specific Effects in Randomized Controlled Trials of Cognitive Remediation for Schizophrenia

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Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer Science+Business Media New York (outside the USA)
Subject
Medicine & Public Health; Psychiatry; Public Health; Sociology, general
ISSN
0033-2720
eISSN
1573-6709
D.O.I.
10.1007/s11126-015-9362-6
Publisher site
See Article on Publisher Site

Abstract

Cognitive remediation (CR) has been found to improve cognitive performance among adults with schizophrenia in randomized controlled trials (RCTs). However, improvements in cognitive performance are often observed in the control groups of RCTs as well. There has been no comprehensive examination of change in control groups for CR, which may inform trial methodology and improve our understanding of measured outcomes for cognitive remediation. In this meta-analysis, we calculated pre–post change in cognitive test performance within control groups of RCTs in 32 CR trials (n = 794 participants) published between 1970 and 2011, and examined the association between pre–post change and sample size, duration of treatment, type of control group, and participants’ age, intelligence, duration of illness, and psychiatric symptoms. Results showed that control groups in CR trials showed small effect size changes (Cohen’s d = 0.12 ± 0.16) in cognitive test performance over the trial duration. Study characteristics associated with pre–post change included participant age and sample size. These findings suggest attention to change in control groups may help improve detection of cognitive remediation effects for schizophrenia.

Journal

Psychiatric QuarterlySpringer Journals

Published: May 8, 2015

References

  • The role of randomization in clinical trials
    Armitage, P
  • Housing arrangements among a national sample of adults with chronic schizophrenia living in the United States: A descriptive study
    Tsai, J; Stroup, TS; Rosenheck, RA

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