A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease?

A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or... Purpose of Review Hundreds of millions of people worldwide are exposed to arsenic via contaminated water. The goal of this study was to identify whether arsenic-associated lung function deficits resemble obstructive- or restrictive-like lung disease, in order to help illuminate a mechanistic pathway and identify at-risk populations. Recent Findings We recently published a qualitative systematic review outlining the body of research on arsenic and non- malignant respiratory outcomes. Evidence from several populations, at different life stages, and at different levels of exposure showed consistent associations of arsenic exposure with chronic lung disease mortality, respiratory symptoms, and lower lung function levels. The published review, however, only conducted a broad qualitative description of the published studies without considering specific spirometry patterns, without conducting a meta-analysis, and without evaluating the dose-response relationship. Summary We searched PubMed and Embase for studies on environmental arsenic exposure and lung function. We performed a meta-analysis using inverse-variance-weighted random effects models to summarize adjusted effect estimates for arsenic and forced expiratory volume in one second (FEV ), forced vital capacity (FVC), and FEV /FVC ratio. Across nine studies, median 1 1 water arsenic levels ranged from 23 to 860 μg/L. The pooled estimated mean difference (MD) comparing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Environmental Health Reports Springer Journals

A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease?

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Medicine/Public Health, general; Environmental Health
eISSN
2196-5412
D.O.I.
10.1007/s40572-018-0192-1
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Hundreds of millions of people worldwide are exposed to arsenic via contaminated water. The goal of this study was to identify whether arsenic-associated lung function deficits resemble obstructive- or restrictive-like lung disease, in order to help illuminate a mechanistic pathway and identify at-risk populations. Recent Findings We recently published a qualitative systematic review outlining the body of research on arsenic and non- malignant respiratory outcomes. Evidence from several populations, at different life stages, and at different levels of exposure showed consistent associations of arsenic exposure with chronic lung disease mortality, respiratory symptoms, and lower lung function levels. The published review, however, only conducted a broad qualitative description of the published studies without considering specific spirometry patterns, without conducting a meta-analysis, and without evaluating the dose-response relationship. Summary We searched PubMed and Embase for studies on environmental arsenic exposure and lung function. We performed a meta-analysis using inverse-variance-weighted random effects models to summarize adjusted effect estimates for arsenic and forced expiratory volume in one second (FEV ), forced vital capacity (FVC), and FEV /FVC ratio. Across nine studies, median 1 1 water arsenic levels ranged from 23 to 860 μg/L. The pooled estimated mean difference (MD) comparing

Journal

Current Environmental Health ReportsSpringer Journals

Published: Apr 10, 2018

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