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Timothy Moran, P. Ameglio, H. Peyton, Gary Schwartz, Paul McHugh (1993)
Blockade of type A, but not type B, CCK receptors postpones satiety in rhesus monkeys.The American journal of physiology, 265 3 Pt 2
S. Lillioja, D. Mott, M. Spraul, R. Ferraro, J. Foley, E. Ravussin, W. Knowler, Peter Bennett, C. Bogardus (1993)
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians.The New England journal of medicine, 329 27
Y. Hirosue, Akio Inui, A. Teranishi, M. Miura, M. Nakajima, M. Okita, Y. Nakajima, N. Himori, Shigeaki Baba, Masato Kasuga (1993)
Cholecystokinin octapeptide analogues suppress food intake via central CCK-A receptors in mice.The American journal of physiology, 265 3 Pt 2
Mohammed Saad, W. Knowler, D. Pettitt, Robert Nelson, Marie Charles, Peter Bennett (1991)
A two-step model for development of non-insulin-dependent diabetes.The American journal of medicine, 90 2
R Rushakoff, I. Goldfine, L. Beccaria, A. Mathur, R. Brand, R. Liddle (1993)
Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia.The Journal of clinical endocrinology and metabolism, 76 2
K. Miyasaka, S. Kanai, M. Ohta, T. Kawanami, A. Kono, A. Funakoshi (1994)
Lack of satiety effect of cholecystokinin (CCK) in a new rat model not expressing the CCK-A receptor geneNeuroscience Letters, 180
C. Kahn (1994)
Insulin Action, Diabetogenes, and the Cause of Type II DiabetesDiabetes, 43
S. Lillioja, D. Mott, J. Zawadzki, A. Young, W. Abbott, W. Knowler, P. Bennett, P. Moll, C. Bogardus (1987)
In Vivo Insulin Action Is Familial Characteristic in Nondiabetic Pima IndiansDiabetes, 36
K. Kawano (1991)
A new rat strain with non-insulin dependent diabetes mellitus, "OLETF", 25
H. Inoue, C. Iannotti, C. Welling, R. Veile, H. Donis-Keller, M. Permutt (1997)
Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM).Genomics, 42 2
S. Wright (1952)
The genetics of quantitative variability.
J. Warram, B. Martin, A. Krolewski, J. Soeldner, C. Kahn (1990)
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.Annals of internal medicine, 113 12
H. Jacob, Donna Brown, R. Bunker, M. Daly, V. Dzau, A. Goodman, G. Koike, V. Křen, T. Kurtz, Å. Lernmark, G. Levan, Y. Mao, A. Pettersson, M. Pravenec, J. Simon, C. Szpirer, J. Szpirer, M. Trolliet, Eric Winer, E. Lander (1995)
A genetic linkage map of the laboratory rat, Rattus norvegicusNature Genetics, 9
S. Takiguchi, Y. Takata, A. Funakoshi, K. Miyasaka, K. Kataoka, Y. Fujimura, T. Goto, A. Kono (1997)
Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats.Gene, 197 1-2
J. Clausen, T. Hansen, C. Bjørbaek, S. Echwald, S. Urhammer, S. Rasmussen, C. Andersen, L. Hansen, K. Almind, O. Pedersen, K. Borch-Johnsen, K. Winther, J. Haraldsdóttir (1995)
Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1The Lancet, 346
E. Lander, D. Botstein (1989)
Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.Genetics, 121 1
S. Lincoln, E. Lander (1992)
Systematic detection of errors in genetic linkage data.Genomics, 14 3
S. Povoski, W. Zhou, D. Longnecker, R. Jensen, S. Mantey, R. Bell (1994)
Stimulation of in vivo pancreatic growth in the rat is mediated specifically by way of cholecystokinin-A receptors.Gastroenterology, 107 4
K. Kawano, T. Hirashima, S. Mori, Yuichi Saitoh, M. Kurosumi, T. Natori (1992)
Spontaneous Long-Term Hyperglycemic Rat With Diabetic Complications: Otsuka Long-Evans Tokushima Fatty (OLETF) StrainDiabetes, 41
C. Bogardus, S. Lillioja, B. Nyomba, F. Zurlo, B. Swinburn, A. Puente, W. Knowler, E. Ravussin, D. Mott, P. Bennett (1989)
Distribution of In Vivo Insulin Action in Pima Indians as Mixture of Three Normal DistributionsDiabetes, 38
P. Zimmet, G. Dowse, P. Bennett (1991)
Hyperinsulinaemia is a predictor of non-insulin-dependent diabetes mellitus.Diabete & metabolisme, 17 1 Pt 2
E. Verspohl, H. Ammon, John Williams, I. Goldfine (1986)
Evidence That Cholecystokinin Interacts with Specific Receptors and Regulates Insulin Release in Isolated Rat Islets of LangerhansDiabetes, 35
C. Bogardus, S. Lillioja, B. Howard, G. Reaven, D. Mott (1984)
Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects.The Journal of clinical investigation, 74 4
E. Lander, E. Lander, P. Green, Jeff Abrahamson, A. Barlow, M. Daly, S. Lincoln, Lee Newburg (1987)
MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations.Genomics, 1 2
K. Ishida, A. Mizuno, Z. Min, T. Sano, K. Shima (1995)
Which is the primary etiologic event in Otsuka Long-Evans Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus, insulin resistance, or impaired insulin secretion?Metabolism: clinical and experimental, 44 7
M. Procházka, S. Lillioja, J. Tait, W. Knowler, D. Mott, M. Spraul, P. Bennett, C. Bogardus (1993)
Linkage of Chromosomal Markers on 4q With a Putative Gene Determining Maximal Insulin Action in Pima IndiansDiabetes, 42
C. Scarpignato, G. Varga, István Dobronyi, M. Papp (1989)
Effect of a new potent CCK antagonist, lorglumide, on caerulein‐ and bombesin‐induced pancreatic secretion and growth in the ratBritish Journal of Pharmacology, 96
Min Zhu, Y. Noma, K. Shima, A. Mizuno, T. Sano (1996)
Poor Capacity for Proliferation of Pancreatic β-Cells in Otsuka-Long-Evans-Tokushima Fatty Rat: A Model of Spontaneous NIDDMDiabetes, 45
A. Paterson, E. Lander, J. Hewitt, Susan Peterson, S. Lincoln, S. Tanksley (1988)
Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphismsNature, 335
Simeon Taylor, D. Accili, Y. Imai (1994)
Insulin Resistance or Insulin Deficiency: Which Is the Primary Cause of NIDDM?Diabetes, 43
D. Gauguier, P. Froguel, V. Parent, C. Bernard, M. Bihoreau, B. Portha, M. James, L. Pénicaud, M. Lathrop, A. Ktorza (1996)
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK ratNature Genetics, 12
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, non-insulin-dependent diabetes mellitus (NIDDM) in humans. The OLETF rat has poor capacity for pancreatic proliferation, which may be the critical pathogenetic event in NIDDM development. Our investigation was designed to identify quantitative trait loci (QTLs) responsible for poor pancreatic proliferation by examining compensatory proliferation of the pancreatic remnant after partial pancreatectomy and performing a genome-wide scan in an F2 intercross obtained by mating the OLETF and the Fischer-344 (F344) rats. We identified a highly significant QTL on rat Chromosome 14 with a maximum lod score of 16.7, which accounts for 55% of the total variance. The QTL co-localizes with the gene encoding cholecystokinin type A receptor (CCKAR) which is likely to mediate the trophic effect of cholecystokinin on pancreas and is defective in the OLETF rat.
Mammalian Genome – Springer Journals
Published: Oct 1, 1998
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