The effects of a long-term blockade of L-type Ca2+ channels on membrane currents and on the number of dihydropyridine binding sites were investigated in skeletal muscle fibers. Ca2+ currents (I Ca) and intramembrane charge movement were monitored using a voltage-clamp technique. The peak amplitude of I Ca increased by more than 40% in fibers that were previously incubated for 24 hr in solutions containing the organic Ca2+ channel blocker nifedipine or in Ca2+-free conditions. A similar incubation period with Cd2+, an inorganic blocker, produced a moderate increase of 20% in peak I Ca. The maximum mobilized charge (Q max) increased by 50% in fibers preincubated in Ca2+-free solutions or in the presence of Cd2+.
The Journal of Membrane Biology – Springer Journals
Published: Mar 15, 1999
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