A locus responsible for osteochondrodysplasia (ocd) is located on rat Chromosome 11

A locus responsible for osteochondrodysplasia (ocd) is located on rat Chromosome 11 Mammalian Genome 11, 464–465 (2000). Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 A locus responsible for osteochondrodysplasia (ocd) is located on rat Chromosome 11 Hiroetsu Suzuki, Sachiyo Fukaya, Kenichi Saito, Katsushi Suzuki Department of Veterinary Physiology, Nippon Veterinary and Animal Science University, 1-7-1 Kyonano-cho, Musashino-shi, Tokyo 180-8602, Japan Received: 30 November 1999 / Accepted: 18 February 2000 Rats of the congenital osteochondrodysplasia (OCD) strain display lethal dwarfing characteristics that are controlled by an autosomal single recessive allele (ocd). External features of these ocd/ocd rats include systemic subcutaneous edema, protruded tongue, cleft plate, and shortening of the extremities, head, body, and tail (Su- zuki et al. 1987, 1988). These ocd/ocd rats also exhibit renal anomalies (Kikukawa et al. 1989a) and die shortly after birth from respiratory insufficiency, resulting from both morphological and functional abnormalities of the respiratory system (Kikukawa et al. 1989b, 1989c). Irregular columnization, expansion of chondro- cytes, widespread areas of necrosis, and weak stainability of gly- cosaminoglycans (GAGs) are observed in the epiphyseal cartilage of ocd/ocd neonates (Kikukawa et al. 1991a). Electron micro- scopic examination of the cartilage reveals a decrease in the size of GAG granules and the presence of large collagen bundles in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

A locus responsible for osteochondrodysplasia (ocd) is located on rat Chromosome 11

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Copyright © 2000 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Anatomy; Zoology
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