Short Communications Incorporating Mouse Genome Mammalian Genome 11, 694–695 (2000). © Springer-Verlag New York Inc. 2000 DOI: 10.1007/s003350010124 A linkage map of distal mouse Chromosome 4 in the vicinity of Ssm1, a strain-specific modifier of methylation Peter Engler, Ursula Storb Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA Received: 19 November 1999 / Accepted: 17 March 2000 Inactive chromosomal regions are often characterized by the pres- coli gpt and SV40 sequences). DNA was cleaved with BamHI and ence of 5-methyl cytosine in CpG dinucleotides and by hypoacety- HpaII. BamHI generates a 1.7-kb fragment that contains six HpaII lated histones. A direct biochemical link between CpG methylation sites (Fig. 2A). Methylated transgenes are resistant to HpaII cleav- and chromatin structure has now been established: MeCP2, a age, while hypomethylated transgenes yield a major fragment of methyl cytosine-binding protein, can recruit histone deacetylases 0.8 kb as well as smaller fragments that are run off the gel. Prog- d/d to methylated DNA (Jones et al. 1998; Nan et al. 1998). Little is eny with the Ssm1 genotype have hypomethylated transgenes b/d known, however, about how methylation patterns are initially es- similar to
Mammalian Genome – Springer Journals
Published: Feb 7, 2014
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