losing their characteristic morphologies and biological functions. To avoid this problem, a hybrid co-culture sys- tem was proposed to elucidate the effect of cellular com- munication on the phenotype of hepatic cells. A monolayer of endothelial cells (ECs) was co-cultured on the surface of a three-dimensional (3D) scaffold embedded with HepG2 cells. In this hybrid co-culture system, the growth of encapsulated hepatic cells is barely inﬂuenced by the co- cultured ECs. However, the liver-special functions of hepatic cells, including the albumin secretion and the expression levels of hepatocyte-speciﬁc genes, are sig- niﬁcantly improved. It is deduced that the improved liver- special functions is likely related to the paracrine mechan- isms. Hence, this hybrid co-culture model may open a window for the co-cultivation of the multi-type of cells as well as the study of cell-cell signaling interaction. * Xiaobo Huang email@example.com * Bin Tang 1 Introduction firstname.lastname@example.org Hepatic tissue engineering is an attractive strategy aiming at Research Institute of Surface Engineering, Taiyuan University of Technology, Taiyuan 030024, China developing a composite tissue construct for the liver 139 Page 2 of 8 J Mater Sci: Mater Med (2017) 28:139 therapeutic replacement [1–3]. The formed tissue constructs Dulbecco’s Modiﬁed Eagle’s Medium (DMEM)
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Aug 10, 2017
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