Ar R CO Me R' N H N CO Me EtOH 2 ArCHO + CO Me + R O Ar R' O 1 2 3 R R' N Three-Component, Catalyst-Free High Regio-Selectivity Keywords Furoacridine Three-component reaction Catalyst-free Regioselectivity Electronic supplementary material The online version of this article (doi:10.1007/s11164-015-1998-1) contains supplementary material, which is available to authorized users. & Xiang-Shan Wang email@example.com School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou 221116, Jiangsu, People’s Republic of China 123 9918 Y. Zhang et al. Introduction It is well known that amsacrine (Fig. 1, left) is an antineoplastic agent on the market, being widely used to treat acute lymphoblastic leukemia . This compound contains a planar fused ring system in the form of an acridine moiety, i.e., a fused tricyclic heterocycle containing a nitrogen atom. It is reported that its derivatives have signiﬁcant biological activities, such as anti-HIV-1 activity , antitumor activity [3, 4], antibacterial activities , and antimalarial activity . In addition, they have also been used as various kinds of inhibitors, for example, anticholinesterase inhibitors , botulinum neurotoxin (BoNT) inhibitors , topoisomerase inhibitors [9, 10], and human carbonic
Research on Chemical Intermediates – Springer Journals
Published: Apr 1, 2015
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