A high-resolution genetic map around waltzer on mouse Chromosome 10 and identification of a new allele of waltzer

A high-resolution genetic map around waltzer on mouse Chromosome 10 and identification of a new... A new autosomal recessive mouse mutation characterized by deafness and circling behavior was recovered during mutagenesis experiments with chlorambucil (CHL). On the basis of allelism tests and linkage analyses, this mutation appears to represent a new allele of waltzer (v) that maps to mouse Chromosome (Chr) 10. We have designated this new allele, Albany waltzer (v Alb). A high-resolution map of the region around v was constructed from data from two intersubspecific backcrosses involving Mus musculus castaneus. The analysis of 648 backcross mice has allowed v Alb to be localized 1.1 ± 0.4 cM distal to D10Mit60 and 0.2 ± 0.2 cM proximal to a cluster of four markers, D10Mit172, D10Mit112, D10Mit48, and D10Mit196. An independent backcross was used to confirm the map order and distances in the v Alb backcross. The two linkage maps were consistent, indicating that the lesion in v Alb, which is presumed to be a deletion based on the known action of CHL, is small and has not significantly altered the map at this level of detection. Additionally, three genes (Ros1, Grik2, and Zfa) were eliminated as possible candidates for v Alb, and several SSLP markers were separated genetically. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

A high-resolution genetic map around waltzer on mouse Chromosome 10 and identification of a new allele of waltzer

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Publisher
Springer-Verlag
Copyright
Copyright © 1997 by Springer-Verlag
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900336
Publisher site
See Article on Publisher Site

Abstract

A new autosomal recessive mouse mutation characterized by deafness and circling behavior was recovered during mutagenesis experiments with chlorambucil (CHL). On the basis of allelism tests and linkage analyses, this mutation appears to represent a new allele of waltzer (v) that maps to mouse Chromosome (Chr) 10. We have designated this new allele, Albany waltzer (v Alb). A high-resolution map of the region around v was constructed from data from two intersubspecific backcrosses involving Mus musculus castaneus. The analysis of 648 backcross mice has allowed v Alb to be localized 1.1 ± 0.4 cM distal to D10Mit60 and 0.2 ± 0.2 cM proximal to a cluster of four markers, D10Mit172, D10Mit112, D10Mit48, and D10Mit196. An independent backcross was used to confirm the map order and distances in the v Alb backcross. The two linkage maps were consistent, indicating that the lesion in v Alb, which is presumed to be a deletion based on the known action of CHL, is small and has not significantly altered the map at this level of detection. Additionally, three genes (Ros1, Grik2, and Zfa) were eliminated as possible candidates for v Alb, and several SSLP markers were separated genetically.

Journal

Mammalian GenomeSpringer Journals

Published: Mar 23, 2009

References

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