Eur J Nutr (2018) 57:339–349 https://doi.org/10.1007/s00394-016-1323-9 ORIGINAL CONTRIBUTION A high‑fat high‑sucrose diet affects the long‑term metabolic fate of grape proanthocyanidins in rats 1,6 2,3 1 Eunice Molinar‑Toribio · Elisabet Fuguet · Sara Ramos‑Romero · 4 5 4 5 Núria Taltavull · Lucía Méndez · M. Rosa Nogués · Isabel Medina · 1 1,7 Josep Lluís Torres · Jara Pérez‑Jiménez Received: 2 April 2016 / Accepted: 29 September 2016 / Published online: 12 October 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract STD + GSE group. In contrast, a tendency towards the Purpose Polyphenol metabolites are key mediators of the formation of conjugated (epi)catechin metabolites in the biological activities of polyphenols. This study aimed to HFHS + GSE group was observed. evaluate the long-term effects of a high-fat high-sucrose Conclusions These results show that a HFHS diet signifi - (HFHS) diet on the metabolism of proanthocyanidins from cantly modifies PA metabolism, probably via: (1) a shift grape seed extract (GSE). in microbial communities not counteracted by the poly- Methods Adult female Wistar–Kyoto rats were fed a stand- phenols themselves; and (2) an up-regulation of hepatic ard (STD) or HFHS diet supplemented or not with GSE enzymes. for 16 weeks. PA metabolites
European Journal of Nutrition – Springer Journals
Published: Oct 12, 2016
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