Res Chem Intermed (2016) 42:8005–8021 DOI 10.1007/s11164-016-2575-y A green synthesis of 1,2,3-triazolyl-pyridine hybrids and evaluation of their antibacterial activity 1 1 • • Ranganathan Raja Archana Sivasubramaniyan 1 1 • • Dinesh Murugan Nagaraj Subbaiah 1 2 • • Jaabil George Shanmugavelan Poovan 1 1 • • Nagarajan Sangaraiah Ponnuswamy Alagusundaram 3 3 Krishnamoorthy Shanmugam Chandrasekaran Manivachagam Received: 25 March 2016 / Accepted: 4 May 2016 / Published online: 12 May 2016 Springer Science+Business Media Dordrecht 2016 Abstract A water mediated microwave assisted synthesis of 1,2,3-triazolyl-pyridine hybrids have been accomplished via one-pot, three-component eco-friendly protocol in excellent yield. Additionally, the synthesis was achieved efﬁciently via environmental friendly microwave assisted solvent-free methodology. All the synthesized hybrids were screened against four human bacterial pathogens Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae and Salmonella typhi. Interestingly, one of the hybrids (4a) is more potent than Streptomycin (standard drug) and some of the hybrids are of equal or moderate activity. Graphical Abstract A water mediated microwave assisted synthesis of 1,2,3-triazolyl- pyridine hybrids have been accomplished via one-pot, three-component eco-friendly protocol in excellent yield. All the synthesized hybrids were screened against four human bacterial pathogens. Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2575-y)
Research on Chemical Intermediates – Springer Journals
Published: May 12, 2016
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