A green organocatalyzed one-pot protocol for efficient synthesis of new substituted pyrimido[4,5-d]pyrimidinones using a Biginelli-like reaction

A green organocatalyzed one-pot protocol for efficient synthesis of new substituted... Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2588- 6) contains supplementary material, which is available to authorized users. & Mehdi Rimaz rimaz.mehdi@gmail.com Department of Chemistry, Payame Noor University, PO Box19395-3697, Tehran, Iran Faculty of Chemistry, Department of Organic Chemistry, Urmia University, Urmia 57154, Iran 123 8186 M. Rimaz et al. Keywords Biginelli-like reaction  Pyrimido[45-d]pyrimidine Arylgylyoxalmonohydrate  Green chemistry  One-pot Introduction One of the main challenges in medicinal chemistry is the design and synthesis of biological compounds [1–6]. Pyrimidopyrimidines are annelated uracils that have attracted considerable interest in recent years. Dipyridamole, a 2,4,6,8-tetrasubsti- tuted pyrimido[5,4-d]pyrimidine is marketed nowadays as a coronary vasodilator (Fig. 1)[7–10]. Many other derivatives have been known to display a wide range of pharmacological activities such as anti-tumor [11–13], anti-viral (as inhibitor of herpes simplex virus reactivation and viral protein synthesis) [14], anti-oxidant (as lipid peroxidation inhibitors) [15], anti-fungal [16], anti-cancer [17] and also their potent inhibitory properties with regard to the tyrosine kinase domain of epidermal growth factor receptor [18], 5-phosphoribosyl-1-pyrophosphate synthetase [19], and dihydrofolate reductase [20] have been fully demonstrated. Thus, the development of a novel, efficient, simple and environmentally friendly method for synthesis of such compounds is important. Green chemistry http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

A green organocatalyzed one-pot protocol for efficient synthesis of new substituted pyrimido[4,5-d]pyrimidinones using a Biginelli-like reaction

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Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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