Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2588- 6) contains supplementary material, which is available to authorized users. & Mehdi Rimaz email@example.com Department of Chemistry, Payame Noor University, PO Box19395-3697, Tehran, Iran Faculty of Chemistry, Department of Organic Chemistry, Urmia University, Urmia 57154, Iran 123 8186 M. Rimaz et al. Keywords Biginelli-like reaction Pyrimido[45-d]pyrimidine Arylgylyoxalmonohydrate Green chemistry One-pot Introduction One of the main challenges in medicinal chemistry is the design and synthesis of biological compounds [1–6]. Pyrimidopyrimidines are annelated uracils that have attracted considerable interest in recent years. Dipyridamole, a 2,4,6,8-tetrasubsti- tuted pyrimido[5,4-d]pyrimidine is marketed nowadays as a coronary vasodilator (Fig. 1)[7–10]. Many other derivatives have been known to display a wide range of pharmacological activities such as anti-tumor [11–13], anti-viral (as inhibitor of herpes simplex virus reactivation and viral protein synthesis) , anti-oxidant (as lipid peroxidation inhibitors) , anti-fungal , anti-cancer  and also their potent inhibitory properties with regard to the tyrosine kinase domain of epidermal growth factor receptor , 5-phosphoribosyl-1-pyrophosphate synthetase , and dihydrofolate reductase  have been fully demonstrated. Thus, the development of a novel, efﬁcient, simple and environmentally friendly method for synthesis of such compounds is important. Green chemistry
Research on Chemical Intermediates – Springer Journals
Published: Jun 7, 2016
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