A green one-pot synthesis of spironaphthopyrano[1,2-b]indeno-7,3′-indolines

A green one-pot synthesis of spironaphthopyrano[1,2-b]indeno-7,3′-indolines Res Chem Intermed (2015) 41:6219–6227 DOI 10.1007/s11164-014-1734-2 A green one-pot synthesis of spironaphthopyrano [1,2-b]indeno-7,3 -indolines • • Shima Asadi Ghodsi Mohammadi Ziarani Mahshid Rahimifard Ali Abolhassani Soorki Received: 30 March 2014 / Accepted: 30 May 2014 / Published online: 17 June 2014 Springer Science+Business Media Dordrecht 2014 Abstract For the first time, spironaphthopyrano[1,2-b]indeno-7,3 -indolines were prepared by cyclo-condensation of 1,3-indandione, isatin, and 2-naphthol under solvent- free and catalyst-free conditions. This procedure is not only environmentally benign but is also a simple, one-pot, three-component procedure with the advantages of easy work- up and mild reaction conditions. The same reaction was investigated with other b- diketones instead of 1,3-indandione, and the results are reported. The compounds syn- thesized were screened for antimicrobial activity. Keywords Catalyst-free  Isatin  Indandione  Spironaphthopyrano[1,2-b]indeno- 7,3 -indolines Introduction Multicomponent reactions have attracted much attention because they are performed without the need to isolate any intermediates. Such procedures reduce time and save both energy and starting materials [1–4]. They have several advantages over two- component reactions, including the simplicity of a one-pot procedure, possible structural variations, and construction of complex molecules. Synthetic or natural heterocyclic compound containing the spirooxindole skeleton are useful, because this structure is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

A green one-pot synthesis of spironaphthopyrano[1,2-b]indeno-7,3′-indolines

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Publisher
Springer Netherlands
Copyright
Copyright © 2014 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-014-1734-2
Publisher site
See Article on Publisher Site

Abstract

Res Chem Intermed (2015) 41:6219–6227 DOI 10.1007/s11164-014-1734-2 A green one-pot synthesis of spironaphthopyrano [1,2-b]indeno-7,3 -indolines • • Shima Asadi Ghodsi Mohammadi Ziarani Mahshid Rahimifard Ali Abolhassani Soorki Received: 30 March 2014 / Accepted: 30 May 2014 / Published online: 17 June 2014 Springer Science+Business Media Dordrecht 2014 Abstract For the first time, spironaphthopyrano[1,2-b]indeno-7,3 -indolines were prepared by cyclo-condensation of 1,3-indandione, isatin, and 2-naphthol under solvent- free and catalyst-free conditions. This procedure is not only environmentally benign but is also a simple, one-pot, three-component procedure with the advantages of easy work- up and mild reaction conditions. The same reaction was investigated with other b- diketones instead of 1,3-indandione, and the results are reported. The compounds syn- thesized were screened for antimicrobial activity. Keywords Catalyst-free  Isatin  Indandione  Spironaphthopyrano[1,2-b]indeno- 7,3 -indolines Introduction Multicomponent reactions have attracted much attention because they are performed without the need to isolate any intermediates. Such procedures reduce time and save both energy and starting materials [1–4]. They have several advantages over two- component reactions, including the simplicity of a one-pot procedure, possible structural variations, and construction of complex molecules. Synthetic or natural heterocyclic compound containing the spirooxindole skeleton are useful, because this structure is

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 17, 2014

References

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