Res Chem Intermed (2015) 41:6219–6227 DOI 10.1007/s11164-014-1734-2 A green one-pot synthesis of spironaphthopyrano [1,2-b]indeno-7,3 -indolines • • Shima Asadi Ghodsi Mohammadi Ziarani Mahshid Rahimifard Ali Abolhassani Soorki Received: 30 March 2014 / Accepted: 30 May 2014 / Published online: 17 June 2014 Springer Science+Business Media Dordrecht 2014 Abstract For the ﬁrst time, spironaphthopyrano[1,2-b]indeno-7,3 -indolines were prepared by cyclo-condensation of 1,3-indandione, isatin, and 2-naphthol under solvent- free and catalyst-free conditions. This procedure is not only environmentally benign but is also a simple, one-pot, three-component procedure with the advantages of easy work- up and mild reaction conditions. The same reaction was investigated with other b- diketones instead of 1,3-indandione, and the results are reported. The compounds syn- thesized were screened for antimicrobial activity. Keywords Catalyst-free Isatin Indandione Spironaphthopyrano[1,2-b]indeno- 7,3 -indolines Introduction Multicomponent reactions have attracted much attention because they are performed without the need to isolate any intermediates. Such procedures reduce time and save both energy and starting materials [1–4]. They have several advantages over two- component reactions, including the simplicity of a one-pot procedure, possible structural variations, and construction of complex molecules. Synthetic or natural heterocyclic compound containing the spirooxindole skeleton are useful, because this structure is
Research on Chemical Intermediates – Springer Journals
Published: Jun 17, 2014
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