Mammalian Short Communications Genome Incorporating Mouse Genome Mammalian Genome 9, 381-384 (1998). © Springer-Verlag New York Inc. 1998 A genetic linkage map of the mouse Chromosome 9 region encompassing the Friend virus susceptibility gene 2 (Fv2) Robert F. Paulson,' Alan Bernstein' 'Program in Molecular Biology and Cancer, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 983, Toronto, Ontario M5G 1X5, Canada 2The Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada Received: 3 November 1997 / Accepted: 30 December 1997 Forty years ago Charlotte Friend first described a cell-free extract In constrast to Fv1 and Fv4, the resistance conferred by the that was capable of inducing erythroleukemia in adult mice (Friend Friend virus susceptibility gene 2 (Fv2) is specific to the SFFV 1957). Since that time, the study of Friend erythroleukemia virus component of Friend virus and does not directly interfere with the has been a powerful system for studying both the initiation and the retroviral life cycle. Two alleles at the Fv2 locus are known, Fv2r progression of leukemia as well as the mechanisms that regulate for resistance and Fv2 5 for sensitivity to infection (Lilly 1970). erythropoiesis. Friend virus is
Mammalian Genome – Springer Journals
Published: Mar 27, 2009
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