OH H N O NH OAc O O EtOH OH CH C(OEt) 3 3 O O X= H, Cl, Br, NO ,OCH 2 3 Keywords Catalysis Four-component reaction Pﬁtzinger’s quinoline synthesis 4-Hydroxycoumarin 4-Hydroxy-2H-pyran-2-one & Kurosh Rad-Moghadam firstname.lastname@example.org Chemistry Department, Islamic Azad University, Tehran-North Branch, Tehran, Iran Chemistry Department, University of Guilan, Rasht, P.O. Box 41335-1914, Iran 123 4402 S. Y. Kalurazi et al. Introduction Multicomponent reactions (MCRs) typically correspond with molecular-diversity- oriented strategies that enable us to reach maximal structural complexities through minimal processes. These reactions, with a strategy that has already been taken by nature with the aid of enzymes, are becoming quite popular in the chemical community due to being designed by merge of several individual compatible reactions which operate in a sequential manner. A recurrent approach in this context is to make use of even simpler starting materials to yield one or more of the substrates in situ. This strategy usually decreases the cost of synthesis and provides a pool of diverse starting molecules for use in the generation of diversely functionalized products. On the other hand; however, multiplication of the reacting components may increase the chance of side reactions. Hence, efﬁcient MCRs
Research on Chemical Intermediates – Springer Journals
Published: Feb 13, 2017
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