A four-component Pfitzinger reaction: synthesis of 2-pyronylquinolin-4-carbamides

A four-component Pfitzinger reaction: synthesis of 2-pyronylquinolin-4-carbamides OH H N O NH OAc O O EtOH OH CH C(OEt) 3 3 O O X= H, Cl, Br, NO ,OCH 2 3 Keywords Catalysis  Four-component reaction  Pfitzinger’s quinoline synthesis 4-Hydroxycoumarin  4-Hydroxy-2H-pyran-2-one & Kurosh Rad-Moghadam radmm@guilan.ac.ir Chemistry Department, Islamic Azad University, Tehran-North Branch, Tehran, Iran Chemistry Department, University of Guilan, Rasht, P.O. Box 41335-1914, Iran 123 4402 S. Y. Kalurazi et al. Introduction Multicomponent reactions (MCRs) typically correspond with molecular-diversity- oriented strategies that enable us to reach maximal structural complexities through minimal processes. These reactions, with a strategy that has already been taken by nature with the aid of enzymes, are becoming quite popular in the chemical community due to being designed by merge of several individual compatible reactions which operate in a sequential manner. A recurrent approach in this context is to make use of even simpler starting materials to yield one or more of the substrates in situ. This strategy usually decreases the cost of synthesis and provides a pool of diverse starting molecules for use in the generation of diversely functionalized products. On the other hand; however, multiplication of the reacting components may increase the chance of side reactions. Hence, efficient MCRs http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

A four-component Pfitzinger reaction: synthesis of 2-pyronylquinolin-4-carbamides

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-017-2885-8
Publisher site
See Article on Publisher Site

Abstract

OH H N O NH OAc O O EtOH OH CH C(OEt) 3 3 O O X= H, Cl, Br, NO ,OCH 2 3 Keywords Catalysis  Four-component reaction  Pfitzinger’s quinoline synthesis 4-Hydroxycoumarin  4-Hydroxy-2H-pyran-2-one & Kurosh Rad-Moghadam radmm@guilan.ac.ir Chemistry Department, Islamic Azad University, Tehran-North Branch, Tehran, Iran Chemistry Department, University of Guilan, Rasht, P.O. Box 41335-1914, Iran 123 4402 S. Y. Kalurazi et al. Introduction Multicomponent reactions (MCRs) typically correspond with molecular-diversity- oriented strategies that enable us to reach maximal structural complexities through minimal processes. These reactions, with a strategy that has already been taken by nature with the aid of enzymes, are becoming quite popular in the chemical community due to being designed by merge of several individual compatible reactions which operate in a sequential manner. A recurrent approach in this context is to make use of even simpler starting materials to yield one or more of the substrates in situ. This strategy usually decreases the cost of synthesis and provides a pool of diverse starting molecules for use in the generation of diversely functionalized products. On the other hand; however, multiplication of the reacting components may increase the chance of side reactions. Hence, efficient MCRs

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Feb 13, 2017

References

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