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D. Pinkel, J. Landegent, Colin Collins, J. Fuscoe, R. Segraves, J. Lucas, J. Gray (1988)
Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.Proceedings of the National Academy of Sciences of the United States of America, 85 23
Maris Laan, Olli Kallioniemi, E. Hellsten, Kari Alitalo, L. Peltonen, A. Palotie (1995)
Mechanically stretched chromosomes as targets for high-resolution FISH mapping.Genome research, 5 1
K. Helou, V. Wallenius, Y. Qiu, Fredrik Öhman, F. Ståhl, K. Klinga-Levan, L. Kindblom, N. Mandahl, J. Jansson, G. Levan (1999)
Amplification and overexpression of the hepatocyte growth factor receptor (HGFR/MET) in rat DMBA sarcomasOncogene, 18
Thomas Haaf, David Ward (1994)
High resolution ordering of YAC contigs using extended chromatin and chromosomes.Human molecular genetics, 3 4
P. Lichter, Chieh-ju Tang, K. Call, G. Hermanson, G. Evans, D. Housman, D. Ward (1990)
High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones.Science, 247 4938
L. Andersson, A. Archibald, M. Ashburner, S. Audun, W. Barendse, J. Bitgood, C. Bottema, T. Broad, S. Brown, D. Burt, C. Charlier, N. Copeland, S. Davis, M. Davisson, J. Edwards, A. Eggen, G. Elgar, J. Eppig, I. Franklin, P. Grewe, T. Gill, J. Graves, R. Hawken, J. Hetzel, J. Womack (1996)
Comparative genome organization of vertebrates. The First International Workshop on Comparative Genome Organization.Mammalian genome : official journal of the International Mammalian Genome Society, 7 10
P. Woon, P. Woon, K. Osoegawa, P. Kaisaki, Baohui Zhao, J. Catanese, D. Gauguier, R. Cox, E. Levy, G. Lathrop, A. Monaco, P. Jong (1998)
Construction and characterization of a 10-fold genome equivalent rat P1-derived artificial chromosome library.Genomics, 50 3
Kosuke Tashiro, M. Hagiya, T. Nishizawa, T. Seki, Manabu Shimonishi, Shin Shimizu, Toshikazu Nakamura (1990)
Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues.Proceedings of the National Academy of Sciences of the United States of America, 87
R. Debry, M. Seldin (1996)
Human/mouse homology relationships.Genomics, 33 3
A. Trezíse, C. Szpirer, M. Buchwald (1992)
Localization of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) in the rat to chromosome 4 and implications for the evolution of mammalian chromosomes.Genomics, 14 4
H. Jacob, Donna Brown, R. Bunker, M. Daly, V. Dzau, A. Goodman, G. Koike, V. Křen, T. Kurtz, Å. Lernmark, G. Levan, Y. Mao, A. Pettersson, M. Pravenec, J. Simon, C. Szpirer, J. Szpirer, M. Trolliet, Eric Winer, E. Lander (1995)
A genetic linkage map of the laboratory rat, Rattus norvegicusNature Genetics, 9
G. Levan (2009)
Nomenclature for G-bands in rat chromosomes.Hereditas, 77 1
M. Heiskanen, L. Peltonen, A. Palotif (1996)
Visual mapping by high resolution FISH.Trends in genetics : TIG, 12 10
A. Walentinsson, Å. Sjöling, K. Helou, K. Klinga-Levan, G. Levan (2000)
Genomewide assessment of genetic alterations in DMBA‐induced rat sarcomas: Cytogenetic, CGH, and allelotype analyses reveal recurrent DNA copy number changes in rat chromosomes 1, 2, 4, and 7Genes, 28
Thomas Gill, Garry Smith, Robert Wissler, Heinz Kunz (1989)
The rat as an experimental animal.Science, 245 4915
A. Feinberg, B. Vogelstein (1983)
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.Analytical biochemistry, 132 1
James Thomas, S. Lee-Lin, E. Green (1999)
Human-mouse comparative mapping of the genomic region containing CDK6: localization of an evolutionary breakpointMammalian Genome, 10
R. Steen, A. Kwitek-Black, Christopher Glenn, J. Gullings-Handley, W. Etten, O. Atkinson, D. Appel, S. Twigger, Melanie Muir, Tim Mull, M. Granados, Mushira Kissebah, Kerri Russo, Robbin Crane, M. Popp, M. Peden, T. Matise, Donna Brown, Jian Lu, S. Kingsmore, P. Tonellato, S. Rozen, D. Slonim, Peter Young, M. Knoblauch, A. Provoost, Detlev Ganten, S. Colman, J. Rothberg, E. Lander, H. Jacob (1999)
A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat.Genome research, 9 6
Takeshi Watanabe, M. Bihoreau, L. McCarthy, S. Kiguwa, H. Hishigaki, Atsushi Tsuji, J. Browne, Y. Yamasaki, A. Mizoguchi‐Miyakita, K. Oga, T. Ono, S. Okuno, N. Kanemoto, E. Takahashi, Kazuhiro Tomita, H. Hayashi, M. Adachi, C. Webber, M. Davis, Susanne Kiel, Catherine Knights, Angela Smith, R. Critcher, Jonathan Miller, T. Thangarajah, P. Day, J. Hudson, Yasuo Irie, T. Takagi, Yusuke Nakamura, P. Goodfellow, G. Lathrop, A. Tanigami, M. James (1999)
A radiation hybrid map of the rat genome containing 5,255 markersNature Genetics, 22
H. Yokota, G. Engh, M. Mostert, B. Trask (1995)
Treatment of cells with alkaline borate buffer extends the capability of interphase FISH mapping.Genomics, 25 2
(1997)
Reevaluation of the chromosomal location of the rat erythropoietin gene
K. Helou, A. Walentinsson, B. Beckmann, Å. Johansson, H. Hedrich, C. Szpirer, K. Klinga-Levan, G. Levan (2001)
Analysis of genetic changes in rat endometrial carcinomas by means of comparative genomic hybridization.Cancer genetics and cytogenetics, 127 2
(2001)
Zoo-FISH reveals 49 chromosomal segments that have been conserved in evolution between rat and mouse
Li Cai, L. Schalkwyk, Andreina Schoeberlein-Stehli, R. Zee, Avrial Smith, T. Haaf, M. Georges, H. Lehrach, K. Lindpaintner, K. Lindpaintner (1997)
Construction and characterization of a 10-genome equivalent yeast artificial chromosome library for the laboratory rat, Rattus norvegicus.Genomics, 39 3
C. Szpirer, J. Szpirer, K. Klinga-Levan, F. Ståhl, G. Levan (1996)
The rat: an experimental animal in search of a genetic map.Folia biologica, 42 4
B. Trask, H. Massa, Sue Kenwrickt, Jane Gitschiert (1991)
Mapping of human chromosome Xq28 by two-color fluorescence in situ hybridization of DNA sequences to interphase cell nuclei.American journal of human genetics, 48 1
G. Levan, J. Szpirer, C. Szpirer, K. Klinga, C. Hanson, M. Islam (1991)
The gene map of the Norway rat (Rattus norvegicus) and comparative mapping with mouse and man.Genomics, 10 3
(1997)
Chromo - somal localization of rat hepatocyte growth factor ( Hgf ) and HGF receptor ( Met ) and characterization of HGF receptor DNA
Tadao Serikawa, Zonghu Cui, N. Yokoi, T. Kuramoto, Y. Kondo, K. Kitada, J. Guénet (1998)
A comparative genetic map of rat, mouse and human genomes.Experimental animals, 47 1
(1998)
Cytogenetic orientation
The development and refinement of the rat genome map is a prerequisite for a continued qualified and fruitful use of this model system for the study of complex traits. In two distinct rat cancer models, recurrent amplification affecting the proximal region of rat Chr 4 was detected. To further characterize this region, we turned to the evolutionarily conserved chromosome segments in human Chr 7 and mouse Chrs 5 and 6 to identify functional and positional candidate genes. By means of single- and dual-color FISH on metaphase, prometaphase, and interphase chromatin, 15 genes in rat Chr 4q11-q23 (Cdk5, Hgf, Dmtf1, Abcb1, Cyp51, Cdk6, Tac1, Asns, Cav1, Met, Wnt2, Cftr, Smoh, Braf, Arhgef5) were mapped and aligned. In the course of this work, six cancer-related rat genes were isolated de novo and partly sequenced. Ten loci were also mapped by FISH in the mouse. The map provides the framework for a more detailed genetic characterization of individual tumor amplicons, but may also be valuable for the analysis of this region in other rat models of human complex disease. In addition, our data facilitate the analysis of events in mammalian chromosomal evolution affecting the region. In a comparison with human sequence data, we found that there is considerable conservation in this region both in gene order and in distances between genes. There is a single evolutionary breakpoint between rat and mouse and two between rat and human. Since our analysis shows that the three breaks all occurred in different positions, they must be independent of one another. The data tend to support the notion that the genomic configuration in rat Chr 4 is ancestral compared with that in humans and mice.
Mammalian Genome – Springer Journals
Published: Feb 19, 2014
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