World J Urol (2017) 35:1233–1240 DOI 10.1007/s00345-016-1980-6 ORIGINAL ARTICLE A double‑blind, placebo‑controlled randomized clinical trial to evaluate the efficacy of tranexamic acid in irrigant solution on blood loss during percutaneous nephrolithotomy: a pilot study from tertiary care center of North India 1 1 Ankur Bansal · Aditi Arora Received: 30 September 2016 / Accepted: 29 November 2016 / Published online: 19 December 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract Conclusions 0.1% tranexamic acid in irrigant fluid is safe Purpose To evaluate the efficacy and safety of 0.1% and significantly reduces perioperative blood loss and tranexamic acid in irrigant fluid in reducing blood loss dur - requirement of blood transfusion during percutaneous ing PCNL. nephrolithotomy. It is associated with lower perioperative Materials and methods The study involved 400 patients complication rates. who were planned for PCNL and were prospectively ran- domized into two equal groups. In tranexamic group, 0.1% Keywords Percutaneous nephrolithotomy · Tranexamic tranexamic acid was given in irrigant fluid, while in pla - acid · Irrigant · Blood loss cebo group, distilled water was added to irrigant fluid dur - ing surgery. Operative data were recorded which included Abbreviations fall in hemoglobin, total blood loss, operative time, irriga-PCNL
World Journal of Urology – Springer Journals
Published: Dec 19, 2016
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