Mammalian Genome 9, 671–672 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice 1 1 2 3 4 1 Gyula Szabó, Géza Dallmann, Géza Müller, László Patthy, Morris Soller, László Varga Agricultural Biotechnology Center, P.O. Box 411, H-2101 Gödöllo ˝ , Hungary Egis Pharmaceuticals Ltd., H-1475 Budapest, Hungary Institute of Enzymology, Hungarian National Academy of Sciences, H-1518 Budapest, Hungary Department of Genetics, The Alexander Silberman Life Science Institute, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel Received: 17 February 1998 / Accepted: 10 April 1998 Mouse myostatin (GDF-8) is a member of the TGF-b superfamily DNA of a normal (BALB/c) individual did not reveal the deletion. of secreted growth and differentiation factors (McPherron et al. This finding, in conjunction with the Genebank sequence, con- 1997). Disruption of the myostatin gene by gene targeting in mice firms that the 12-bp deletion is not solely a polymorphic difference caused a large and widespread increase in skeletal muscle mass between the HCI and NMRI strains. resulting from a combination of muscle cell hyperplasia and hy- For genotyping the deletion, a reverse primer was designed and pertrophy. These
Mammalian Genome – Springer Journals
Published: Aug 1, 1998
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