A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice

A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice Mammalian Genome 9, 671–672 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice 1 1 2 3 4 1 Gyula Szabó, Géza Dallmann, Géza Müller, László Patthy, Morris Soller, László Varga Agricultural Biotechnology Center, P.O. Box 411, H-2101 Gödöllo ˝ , Hungary Egis Pharmaceuticals Ltd., H-1475 Budapest, Hungary Institute of Enzymology, Hungarian National Academy of Sciences, H-1518 Budapest, Hungary Department of Genetics, The Alexander Silberman Life Science Institute, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel Received: 17 February 1998 / Accepted: 10 April 1998 Mouse myostatin (GDF-8) is a member of the TGF-b superfamily DNA of a normal (BALB/c) individual did not reveal the deletion. of secreted growth and differentiation factors (McPherron et al. This finding, in conjunction with the Genebank sequence, con- 1997). Disruption of the myostatin gene by gene targeting in mice firms that the 12-bp deletion is not solely a polymorphic difference caused a large and widespread increase in skeletal muscle mass between the HCI and NMRI strains. resulting from a combination of muscle cell hyperplasia and hy- For genotyping the deletion, a reverse primer was designed and pertrophy. These http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice

Loading next page...
 
/lp/springer_journal/a-deletion-in-the-myostatin-gene-causes-the-compact-cmpt-hypermuscular-GwMp3F0mkn
Publisher
Springer-Verlag
Copyright
Copyright © 1998 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/PL00022811
Publisher site
See Article on Publisher Site

Abstract

Mammalian Genome 9, 671–672 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice 1 1 2 3 4 1 Gyula Szabó, Géza Dallmann, Géza Müller, László Patthy, Morris Soller, László Varga Agricultural Biotechnology Center, P.O. Box 411, H-2101 Gödöllo ˝ , Hungary Egis Pharmaceuticals Ltd., H-1475 Budapest, Hungary Institute of Enzymology, Hungarian National Academy of Sciences, H-1518 Budapest, Hungary Department of Genetics, The Alexander Silberman Life Science Institute, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel Received: 17 February 1998 / Accepted: 10 April 1998 Mouse myostatin (GDF-8) is a member of the TGF-b superfamily DNA of a normal (BALB/c) individual did not reveal the deletion. of secreted growth and differentiation factors (McPherron et al. This finding, in conjunction with the Genebank sequence, con- 1997). Disruption of the myostatin gene by gene targeting in mice firms that the 12-bp deletion is not solely a polymorphic difference caused a large and widespread increase in skeletal muscle mass between the HCI and NMRI strains. resulting from a combination of muscle cell hyperplasia and hy- For genotyping the deletion, a reverse primer was designed and pertrophy. These

Journal

Mammalian GenomeSpringer Journals

Published: Aug 1, 1998

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off