An efficient and improved process for the synthesis of novel 1-indanones derivatives has been developed. In the first step of the presented new process, 4-bromobenzaldehyde reacts with 5, 6-dimethoxy-2, 3-dihydro-1H-inden-1-one by N-arylation of corresponding compounds with a variety of aliphatic and aromatic amines to produce a novel category of 1-indanones as the final step. Comparison of this newly designed method with conventional methods show that our method is much more efficient in producing a higher total yield. This innovative synthesis methodology offers several advantages, among which the consumption of inexpensive reagents and the resulting higher total yields of final products are of its remarkable points.
Research on Chemical Intermediates – Springer Journals
Published: Apr 23, 2016
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