Mammalian Genome 13, 664–666 (2002). DOI: 10.1007/s00335-002-2183-6 A congenic strain of rat for investigation of control of estrogen-induced growth 1 1 2 Douglas L. Wendell, Jyotsna Pandey, Parker Kelley Department of Biological Sciences, Oakland University, Rochester, MI, 48309-4401, USA Department of Biochemistry, University of Wisconsin, Madison, WI, 53706, USA Received: 20 March 2002 / Accepted: 7 August 2002 The rat pituitary has been used for several decades as a model strategy (Markel et al. 1997) (Fig. 1). At each generation, system to investigate the role of estrogen in tumor growth, cell animals were selected that bore the BN allele of microsatellites proliferation, and angiogenesis. A major reason for using the from the markers across the 2-LOD support interval of rat pituitary is the great diﬀerence between laboratory rat Edpm3. The resulting congenic strain, named F344/NHsd- BN strains in the eﬀect of chronic estrogen treatment on pituitary Edpm3 in accordance with the guidelines of the Committee tumor growth (Wiklund and Gorski 1982; Wendell et al. 1996; on Rat Nomenclature (1992), is homozygous for BN alleles Spady et al. 1999). For example, when rats of the inbred strain over the majority of rat Chr3. The animals were homozygous Fischer 344 (F344)
Mammalian Genome – Springer Journals
Published: Nov 1, 2002
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