Objective Differentiation between benign and malignant ovarian neoplasms is essential to create a system for patient referrals. Therefore, tumor markers such as CA-125 and human epididymis protein 4 (HE-4) as well as the risk ovarian malignancy algorithm (ROMA) and risk malignancy index (RMI) values were considered individually and in combination to evaluate their utility in referral of women at a high risk of having an ovarian malignancy to cancer centers where multidisciplinary input is available. Methods Patients who were diagnosed with an adnexal mass through imaging analyses or clinically (n = 35) were assessed for their expression of the tumor markers CA-125 and HE-4 and were ﬁnally compared to the histopathology of the tumor after surgery which has been taken as the gold standard. The ROMA and RMI values were also determined. The sensitivity, speciﬁcity, PPV, NPV, PLR and NLR of each parameter were calculated. Two different sets of analysis were made: one including benign and borderline masses together and the other including malignant and borderline masses together. Results The sensitivity of ROMA (91%) was highest when compared to RMI, CA-125 and HE-4. Speciﬁcity and positive likelihood ratio of HE-4 were highest at 87.5% and 5.1, respectively, when compared
Indian Journal of Gynecologic Oncology – Springer Journals
Published: Dec 30, 2017
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