A Comparative Study of RMI and ROMA in Women Presenting with an Adnexal Mass

A Comparative Study of RMI and ROMA in Women Presenting with an Adnexal Mass Objective Differentiation between benign and malignant ovarian neoplasms is essential to create a system for patient referrals. Therefore, tumor markers such as CA-125 and human epididymis protein 4 (HE-4) as well as the risk ovarian malignancy algorithm (ROMA) and risk malignancy index (RMI) values were considered individually and in combination to evaluate their utility in referral of women at a high risk of having an ovarian malignancy to cancer centers where multidisciplinary input is available. Methods Patients who were diagnosed with an adnexal mass through imaging analyses or clinically (n = 35) were assessed for their expression of the tumor markers CA-125 and HE-4 and were finally compared to the histopathology of the tumor after surgery which has been taken as the gold standard. The ROMA and RMI values were also determined. The sensitivity, specificity, PPV, NPV, PLR and NLR of each parameter were calculated. Two different sets of analysis were made: one including benign and borderline masses together and the other including malignant and borderline masses together. Results The sensitivity of ROMA (91%) was highest when compared to RMI, CA-125 and HE-4. Specificity and positive likelihood ratio of HE-4 were highest at 87.5% and 5.1, respectively, when compared http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Gynecologic Oncology Springer Journals

A Comparative Study of RMI and ROMA in Women Presenting with an Adnexal Mass

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Publisher
Springer India
Copyright
Copyright © 2017 by Association of Gynecologic Oncologists of India
Subject
Medicine & Public Health; Oncology; Surgical Oncology
ISSN
2363-8397
eISSN
2363-8400
D.O.I.
10.1007/s40944-017-0168-3
Publisher site
See Article on Publisher Site

Abstract

Objective Differentiation between benign and malignant ovarian neoplasms is essential to create a system for patient referrals. Therefore, tumor markers such as CA-125 and human epididymis protein 4 (HE-4) as well as the risk ovarian malignancy algorithm (ROMA) and risk malignancy index (RMI) values were considered individually and in combination to evaluate their utility in referral of women at a high risk of having an ovarian malignancy to cancer centers where multidisciplinary input is available. Methods Patients who were diagnosed with an adnexal mass through imaging analyses or clinically (n = 35) were assessed for their expression of the tumor markers CA-125 and HE-4 and were finally compared to the histopathology of the tumor after surgery which has been taken as the gold standard. The ROMA and RMI values were also determined. The sensitivity, specificity, PPV, NPV, PLR and NLR of each parameter were calculated. Two different sets of analysis were made: one including benign and borderline masses together and the other including malignant and borderline masses together. Results The sensitivity of ROMA (91%) was highest when compared to RMI, CA-125 and HE-4. Specificity and positive likelihood ratio of HE-4 were highest at 87.5% and 5.1, respectively, when compared

Journal

Indian Journal of Gynecologic OncologySpringer Journals

Published: Dec 30, 2017

References

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