Purpose The use of surgical antibiotic prophylaxis (SAP) in vention: 784; post-intervention: 790; follow-up: 809). The QI children is poorly characterized. Our aim was to evaluate the intervention had a significant impact on the adherence to SAP effectiveness of a quality improvement (QI) intervention indications (86.6% in the post-intervention, compared to 82.0% targeting SAP in children, by means of a multicenter prospective prior to the intervention; p < 0.05), and on its appropriateness intervention study, with a before and after design. (35.7% compared to 19.9%; p < 0.01). The impact of the inter- Methods We prospectively investigated elective surgical proce- vention on SAP appropriateness was maintained at follow-up dures performed in children <18 years, prior to the QI interven- (38.3%; p < 0.01 compared to pre-intervention). All components tion, after the intervention and at 9-month follow-up. The prima- of SAP appropriateness significantly improved after the interven- ry outcomes were adherence to SAP indications and SAP appro- tion and at follow-up. The logistic regression analyses confirmed priateness, defined considering antibiotic choice, timing of first the effect of intervention in improving adherence to SAP indica- dose and duration of administration. We compared SAP adher- tions and appropriateness. ence and appropriateness prior
European Journal of Clinical Pharmacology – Springer Journals
Published: Jun 7, 2017
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