An atom-efficient, one-pot, three-component synthetic method, using silica–sulfuric acid nanoparticles as catalyst, has been developed for preparation of biologically important spirooxindoles. The reaction involves the use of isatin or 5-fluoroisatin, malononitrile, and enolizable systems. A wide range of enolizable systems can be used in this reaction, furnishing excellent yields in a short time. The catalyst is recyclable with reproducible results without any loss of its activity. The morphology of the silica–sulfuric acid nanoparticles was observed by scanning electron microscopy. Some of the compounds were new and their structures were deduced by elemental and spectral analysis (IR, 1H NMR, and 13C NMR). Moreover, column chromatography and recrystallization of the products is not required because the crude products are already highly pure.
Research on Chemical Intermediates – Springer Journals
Published: Dec 31, 2013
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