A case of non-monotonous influence of pressure on enantioselectivity in supercritical fluid chromatography

A case of non-monotonous influence of pressure on enantioselectivity in supercritical fluid... non-monotonous dependence of selectivity coefficient on pressure in the enantioseparation of salbutamol sulfate by supercritical fluid chromatography was discovered. When increasing the isothermal pressure of the mobile phase in the interval 100—200 bar at a temperature of 20 °С, the selectivity coefficient of separation of salbutamol enantiomers first increased, then decreased, followed by another increase. Such a behavior is atypical and determines the expediency of using pressure to control selectivity in this kind of chromatography. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Chemical Bulletin Springer Journals

A case of non-monotonous influence of pressure on enantioselectivity in supercritical fluid chromatography

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Chemistry; Chemistry/Food Science, general; Organic Chemistry; Inorganic Chemistry
ISSN
1066-5285
eISSN
1573-9171
D.O.I.
10.1007/s11172-017-2001-7
Publisher site
See Article on Publisher Site

Abstract

non-monotonous dependence of selectivity coefficient on pressure in the enantioseparation of salbutamol sulfate by supercritical fluid chromatography was discovered. When increasing the isothermal pressure of the mobile phase in the interval 100—200 bar at a temperature of 20 °С, the selectivity coefficient of separation of salbutamol enantiomers first increased, then decreased, followed by another increase. Such a behavior is atypical and determines the expediency of using pressure to control selectivity in this kind of chromatography.

Journal

Russian Chemical BulletinSpringer Journals

Published: Mar 14, 2018

References

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