Infertility in humans and subfertility in domestic animals are two major reproductive problems. Among human couples, ~15 % are diagnosed as infertile, and males are considered responsible in about 50 % of the cases. To examine male fertility, various sperm tests including analyses of sperm morphology, sperm count and sperm mobility are usually performed. Teratozoospermia, a condition characterized by the presence of morphologically abnormal sperm, is considered as a symptom of infertility. B10.MOL-TEN1 (TEN1) mice (Mus musculus) show inherited teratozoospermia at high frequencies (~50 %). In this study, the polygenic control of teratozoospermia in the TEN1 strain was analysed. A quantitative trait loci analysis indicated three statistically significant loci, Sperm-head morphology 3 (Shm3; logarithm of the odds (LOD) score, 29.25), Shm4 (LOD score, 6.80), and Shm5 (LOD score, 3.58). These three QTL peaks were mapped to 24.3 centimorgans (cM) on chromosome 1, 32.0 cM on chromosome X, and 63.8 cM on chromosome 6, respectively. Another locus that is yet to be determined was also predicted. Shm3 was found to be the major locus responsible for teratozoospermia, and a sequential cascade of interactions of the other three loci was apparent. These results are expected to help understand the mechanisms underlying reproductive problems in humans or domestic animals.
Mammalian Genome – Springer Journals
Published: May 12, 2015
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera